Hs02271348_cn

• Gene Symbol: NFKB2
• Assay Reference Genome Location: Chr.10:102396503 on build GRCh38
• Cytoband: 10q24.32

Target Gene Details

• Entrez Gene ID: 4791
• Gene Name: nuclear factor kappa B subunit 2
• Gene Aliases: CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52
• Location: Chr.10:102394110-102402529 on Build GRCh38
• Assay Gene Location: Overlaps Exon 4 - Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NFKB2	NM_001077494.3			NP_001070962.1
	NM_001261403.2			NP_001248332.1
	NM_001288724.1			NP_001275653.1
	NM_001322934.1			NP_001309863.1
	NM_001322935.1			NP_001309864.1
	NM_002502.5			NP_002493.3
	XM_011539830.2			XP_011538132.1
	XM_017016278.1			XP_016871767.1
	AK292654.1
	BC002844.2			AAH02844.1
	BT009769.1			AAP88771.1
	BY799958.2
	DA349980.1
	DA408461.1
	DA711063.1
	S76638.1			AAB21124.1
	U09609.2			AAA21462.2
	X61498.1			CAA43715.1
	X61499.1			CAA43716.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1159761	Chr.10:102372778 - 102430809 on Build GRCh38	Deletion	CUEDC2 FBXL15 PSD GBF1 NFKB2
nsv526665	Chr.10:102363085 - 102397954 on Build GRCh38	Loss	GBF1 NFKB2
nsv525546	Chr.10:102380593 - 102415138 on Build GRCh38	Loss	PSD GBF1 NFKB2
nsv951006	Chr.10:102394644 - 102425743 on Build GRCh38	Deletion	CUEDC2 FBXL15 PSD NFKB2

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

Rel homology transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
follicular dendritic cell differentiation
germinal center formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
inflammatory response
I-kappaB kinase/NF-kappaB signaling
aging
extracellular matrix organization
positive regulation of type I interferon production
response to lipopolysaccharide
response to cytokine
NIK/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
spleen development
positive regulation of NF-kappaB transcription factor activity

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding