Hs02509147_cn

• Gene Symbol: GZMB
• Assay Reference Genome Location: Chr.14:24634156 on build GRCh38
• Cytoband: 14q12

Target Gene Details

• Entrez Gene ID: 3002
• Gene Name: granzyme B
• Gene Aliases: CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
• Location: Chr.14:24630954-24634226 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GZMB	NM_004131.4	1	71	NP_004122.2
	XM_011536685.2			XP_011534987.1
	AY232654.1			AAP70244.1
	AY232655.1			AAP70245.1
	AY232656.1			AAP70246.1
	AY372494.1	1	112	AAR23323.1
	BC030195.1			AAH30195.1
	BX283601.1	1	73
	J03189.1			AAA36603.1
	J04071.1			AAA52118.1
	M17016.1			AAA36627.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv510631	Chr.14:24575977 - 24703105 on Build GRCh38	Deletion	GZMH CTSG GZMB

More Information

Additional Information:

• Set Membership: Intragenic, Exonic, DGV Variation, Validated

Panther Classification:

Molecular Function -

protease, serine protease, protein modifying enzyme

Gene Ontology Categories:

Process(es)

apoptotic process
protein processing
cytolysis
natural killer cell mediated cytotoxicity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Function(s)

serine-type endopeptidase activity
protein binding
serine-type peptidase activity