Hs02607820_cn

• Gene Symbol: ALOX12
• Assay Reference Genome Location: Chr.17:7006036 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 239
• Gene Name: arachidonate 12-lipoxygenase, 12S type
• Gene Aliases: 12-LOX, 12S-LOX, LOG12
• Location: Chr.17:6993791-7010736 on Build GRCh38
• Assay Gene Location: Overlaps Exon 10 - Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12	NM_000697.2			NP_000688.2
	XM_011523780.2			XP_011522082.1
	BC069557.1			AAH69557.1
	M35418.1			AAA60056.1
	M58704.1			AAA59523.1
	M62982.1			AAA51533.1

Target Gene Details

• Entrez Gene ID: 100506713
• Gene Name: ALOX12 antisense RNA 1
• Gene Aliases: -
• Location: Chr.17:6985123-7012334 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12-AS1	NR_040089.1
	BI559919.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422288	Chr.17:6789933 - 7646709 on Build GRCh38	Deletion	SNORD10 TMEM95 ACAP1 ALOX12P2 YBX2 ASGR2 GPS2 RNASEK-C17orf49 CLDN7 TNFSF13 DVL2 SNORA67 TMEM256 TNFSF12-TNFSF13 TNK1 MIR497HG ALOX12-AS1 SENP3 LOC100996842 TNFSF12 NLGN2 EIF5A CHRNB1 BCL6B NEURL4 ZBTB4 ATP1B2 ASGR1 EIF4A1 SPEM1 SAT2 TEKT1 GABARAP SLC16A11 POLR2A RNASEK SENP3-EIF4A1 TMEM256-PLSCR3 SLC16A13 TMEM102 ACADVL CLEC10A FGF11 ALOX12 PLSCR3 PHF23 SHBG LOC107983988 FBXO39 CTDNEP1 FXR2 MIR497 CD68 MIR324 KCTD11 SLC2A4 C17orf49 SLC35G6 ELP5 MIR195 SOX15 DLG4 C17orf74 MPDU1 SNORA48
esv1008363	Chr.17:7005907 - 7006407 on Build GRCh38	Loss	ALOX12 ALOX12-AS1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

movement of cell or subcellular component
aging
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
arachidonic acid metabolic process
lipoxygenase pathway
fatty acid oxidation
positive regulation of cell growth
positive regulation of cell migration
superoxide anion generation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
linoleic acid metabolic process
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of vasodilation
positive regulation of smooth muscle cell proliferation
hepoxilin metabolic process
hepoxilin biosynthetic process
positive regulation of mitochondrial depolarization
establishment of skin barrier
cellular response to lipid
reactive oxygen species metabolic process
negative regulation of platelet aggregation
leukotriene A4 metabolic process
lipoxin metabolic process
lipoxin A4 biosynthetic process
lipoxin B4 biosynthetic process

Function(s)

arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
linoleate 13S-lipoxygenase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hepoxilin-epoxide hydrolase activity
hepoxilin A3 synthase activity