Hs02678371_cn

• Gene Symbol: NCOA3
• Assay Reference Genome Location: Chr.20:47655248 on build GRCh38
• Cytoband: 20q13.12

Target Gene Details

• Entrez Gene ID: 8202
• Gene Name: nuclear receptor coactivator 3
• Gene Aliases: ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP
• Location: Chr.20:47501857-47656877 on Build GRCh38
• Assay Gene Location: Within Exon 23

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NCOA3	NM_001174087.1	23	6364	NP_001167558.1
	NM_001174088.1	23	6340	NP_001167559.1
	NM_006534.3	23	6355	NP_006525.2
	NM_181659.2	23	6367	NP_858045.1
	AF012108.1	23	6294	AAC51677.1
	AF036892.1	23	6253	AAB92368.1
	BC119001.1	23	6243
	BC122547.1	23	6239

Target Gene Details

• Entrez Gene ID: 55959
• Gene Name: sulfatase 2
• Gene Aliases: HSULF-2
• Location: Chr.20:47654584-47786629 on Build GRCh38
• Assay Gene Location: Within Exon 23

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SULF2	XM_005260458.2	21	5972	XP_005260515.1
	XM_017027955.1	21	6044	XP_016883444.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2758799	Chr.20:47639666 - 47895335 on Build GRCh38	Gain	NCOA3 SULF2
nsv1066907	Chr.20:47310827 - 47736827 on Build GRCh38	Gain	LOC100131496 LOC101927377 NCOA3 SULF2 ZMYND8
nsv833995	Chr.20:47550035 - 47694664 on Build GRCh38	Loss	NCOA3 SULF2

More Information

Additional Information:

For this assay, SNP(s) [rs187155333] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

histone modifying enzyme, hydrolase

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
positive regulation of gene expression
histone acetylation
androgen receptor signaling pathway
intracellular receptor signaling pathway
receptor transactivation
positive regulation of keratinocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to estradiol stimulus
regulation of RNA biosynthetic process
kidney development
chondrocyte development
glomerular filtration
response to wounding
positive regulation of vascular endothelial growth factor production
esophagus smooth muscle contraction
positive regulation of Wnt signaling pathway
heparan sulfate proteoglycan metabolic process
glomerular basement membrane development
positive regulation of catenin import into nucleus
glial cell-derived neurotrophic factor receptor signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
embryonic skeletal system development
cartilage development
bone development
innervation
positive regulation of canonical Wnt signaling pathway
liver regeneration
regulation of hepatocyte proliferation

Function(s)

transcription coactivator activity
histone acetyltransferase activity
protein binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
thyroid hormone receptor binding
protein dimerization activity
protein N-terminus binding
androgen receptor binding
arylsulfatase activity
calcium ion binding
N-acetylglucosamine-6-sulfatase activity