Hs02802247_cn

• Gene Symbol: ERCC1
• Assay Reference Genome Location: Chr.19:45475182 on build GRCh38
• Cytoband: 19q13.32

Target Gene Details

• Entrez Gene ID: 2067
• Gene Name: ERCC excision repair 1, endonuclease non-catalytic subunit
• Gene Aliases: COFS4, RAD10, UV20
• Location: Chr.19:45407333-45478866 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ERCC1	XM_005258636.4			XP_005258693.1
	XM_017026464.1			XP_016881953.1
	AK092039.1

Target Gene Details

• Entrez Gene ID: 2354
• Gene Name: FosB proto-oncogene, AP-1 transcription factor subunit
• Gene Aliases: AP-1, G0S3, GOS3, GOSB
• Location: Chr.19:45467995-45475179 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FOSB	NM_001114171.1			NP_001107643.1
	NM_006732.2			NP_006723.2
	XM_005258691.1			XP_005258748.1
	AF432216.1
	BC036724.1			AAH36724.1
	BC040197.1			AAH40197.1
	D16366.1
	EU178109.1
	EU178110.1
	EU178111.1
	EU178112.1
	EU178113.1
	EU178114.1
	EU178115.1
	EU178116.1
	L49169.1			AAB53946.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833848	Chr.19:45457372 - 45644939 on Build GRCh38	Loss	OPA3 FOSB EML2 MIR330 EML2-AS1 PPM1N RTN2 GPR4 VASP ERCC1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

endodeoxyribonuclease, basic leucine zipper transcription factor

Gene Ontology Categories:

Process(es)

pyrimidine dimer repair by nucleotide-excision repair
replicative cell aging
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
DNA recombination
mitotic recombination
syncytium formation
response to oxidative stress
spermatogenesis
response to nutrient
cell proliferation
male gonad development
UV protection
response to sucrose
response to X-ray
multicellular organism aging
negative regulation of telomere maintenance
nucleotide-excision repair, DNA incision
post-embryonic hemopoiesis
multicellular organism growth
interstrand cross-link repair
isotype switching
oogenesis
embryonic organ development
global genome nucleotide-excision repair
t-circle formation
positive regulation of t-circle formation
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
female pregnancy
response to mechanical stimulus
response to progesterone
cellular response to hormone stimulus
response to drug
response to morphine
positive regulation of transcription from RNA polymerase II promoter
response to corticosterone
response to cAMP
cellular response to calcium ion

Function(s)

single-stranded DNA endodeoxyribonuclease activity
TFIID-class transcription factor binding
damaged DNA binding
single-stranded DNA binding
protein binding
protein C-terminus binding
protein domain specific binding
structure-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor binding