Hs02804707_cn

• Gene Symbol: ARHGAP22
• Assay Reference Genome Location: Chr.10:48431328 on build GRCh38
• Cytoband: 10q11.22

Target Gene Details

• Entrez Gene ID: 58504
• Gene Name: Rho GTPase activating protein 22
• Gene Aliases: RhoGAP2, RhoGap22
• Location: Chr.10:48429831-48656265 on Build GRCh38
• Assay Gene Location: Within Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARHGAP22	XM_011540013.2			XP_011538315.1
	XM_017016473.1			XP_016871962.1
	XM_017016476.1			XP_016871965.1

Target Gene Details

• Entrez Gene ID: 5599
• Gene Name: mitogen-activated protein kinase 8
• Gene Aliases: JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
• Location: Chr.10:48306639-48439360 on Build GRCh38
• Assay Gene Location: Overlaps Exon 14 - Intron 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAPK8	NM_001278547.1			NP_001265476.1
	NM_001278548.1			NP_001265477.1
	NM_001323302.1			NP_001310231.1
	NM_001323320.1			NP_001310249.1
	NM_001323321.1			NP_001310250.1
	NM_001323322.1			NP_001310251.1
	NM_001323323.1			NP_001310252.1
	NM_001323324.1			NP_001310253.1
	NM_001323325.1			NP_001310254.1
	NM_001323326.1			NP_001310255.1
	NM_001323327.1			NP_001310256.1
	NM_001323328.1			NP_001310257.1
	NM_001323329.1			NP_001310258.1
	NM_001323330.1			NP_001310259.1
	NM_001323331.1			NP_001310260.1
	NM_139046.3			NP_620634.1
	NM_139049.3			NP_620637.1
	NR_136583.1
	NR_136584.1
	NR_136585.1
	AB451231.1
	AB451271.1
	AB451354.1
	AB451398.1
	AK094000.1
	AK292523.1
	AL137667.1
	BC130570.1
	BC130572.1
	BC144063.1
	DQ234352.1			ABB29981.1
	L26318.1			AAA36131.1
	U34822.1			AAC50607.1
	U35004.1			AAC50610.1
	U35005.1			AAC50611.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv519701	Chr.10:48428464 - 48443306 on Build GRCh38	Loss	MAPK8 ARHGAP22
nsv1039508	Chr.10:48387675 - 48446360 on Build GRCh38	Gain	MAPK8 ARHGAP22
nsv1042677	Chr.10:47993784 - 49928329 on Build GRCh38	Loss	FAM25C C10orf71 C10orf53 ERCC6 OGDHL C10orf71-AS1 FAM170B C10orf128 PARG MAPK8 SLC18A3 AGAP12P WDFY4 CHAT DRGX VSTM4 FRMPD2 FAM170B-AS1 MIR4294 LRRC18 PGBD3 ARHGAP22

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

angiogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
signal transduction
cell differentiation
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
protein phosphorylation
response to stress
JNK cascade
JUN phosphorylation
response to UV
positive regulation of gene expression
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
regulation of histone deacetylation
positive regulation of cyclase activity
negative regulation of protein binding
regulation of protein localization
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of apoptotic process
negative regulation of apoptotic process
rhythmic process
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of protein metabolic process
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
positive regulation of deacetylase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Function(s)

GTPase activator activity
protein binding
protein serine/threonine kinase activity
JUN kinase activity
ATP binding
kinase activity
enzyme binding
histone deacetylase regulator activity
histone deacetylase binding