Hs03001912_cn

• Gene Symbol: THRB
• Assay Reference Genome Location: Chr.3:24120961 on build GRCh38
• Cytoband: 3p24.2

Target Gene Details

• Entrez Gene ID: 7068
• Gene Name: thyroid hormone receptor beta
• Gene Aliases: C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
• Location: Chr.3:24117153-24495281 on Build GRCh38
• Assay Gene Location: Within Exon 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THRB	NM_000461.4	10	3594	NP_000452.2
	NM_001128176.2	11	3705	NP_001121648.1
	NM_001128177.1	11	3731	NP_001121649.1
	NM_001252634.1	12	3829	NP_001239563.1
	XM_005265421.4	11	3802	XP_005265478.1
	XM_005265423.4	10	3637	XP_005265480.1
	XM_005265424.3	10	3572	XP_005265481.1
	XM_006713317.3	11	3945	XP_006713380.1
	XM_006713318.3	11	3897	XP_006713381.1
	XM_011534046.2	11	5845	XP_011532348.1
	XM_011534047.2	12	4082	XP_011532349.1
	XM_011534048.2	11	3661	XP_011532350.1
	XM_011534049.2	10	3517	XP_011532351.1
	XM_011534050.2	11	3890	XP_011532352.1
	XM_011534051.2	10	3480	XP_011532353.1
	XM_011534052.2	11	3617	XP_011532354.1
	XM_011534053.2	10	3738	XP_011532355.1
	XM_017007108.1	12	4015	XP_016862597.1
	XM_017007109.1	13	4173	XP_016862598.1
	XM_017007110.1	12	3980	XP_016862599.1
	XM_017007111.1	11	3626	XP_016862600.1
	XM_017007112.1	10	3596	XP_016862601.1
	XM_017007113.1	9	3735	XP_016862602.1
	XM_017007114.1	9	3700	XP_016862603.1
	XM_017007115.1	9	3574	XP_016862604.1
	AK095776.1	1	1023
	GQ869477.1	1	1923
	GQ869478.1	1	1923

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834639	Chr.3:23995622 - 24192434 on Build GRCh38	Gain	THRB LOC101927854 LINC00691

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
sensory perception of sound
negative regulation of female receptivity
regulation of heart contraction
female courtship behavior
organ morphogenesis
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
Type I pneumocyte differentiation

Function(s)

DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription corepressor activity
thyroid hormone receptor activity
protein binding
zinc ion binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
thyroid hormone binding