Hs03011602_cn

• Gene Symbol: MCL1
• Assay Reference Genome Location: Chr.1:150576925 on build GRCh38
• Cytoband: 1q21.2

Target Gene Details

• Entrez Gene ID: 4170
• Gene Name: BCL2 family apoptosis regulator
• Gene Aliases: BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
• Location: Chr.1:150574551-150579738 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MCL1	NM_001197320.1	4	1252	NP_001184249.1
	NM_021960.4	3	1711	NP_068779.1
	NM_182763.2	2	1463	NP_877495.1
	AF118124.1	3	1552	AAD13299.1
	AK294462.1	4	1283
	AK304775.1
	BC017197.2	3	1557	AAH17197.1
	BC071897.1	3	1559	AAH71897.1
	L08246.1	3	1563

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1006838	Chr.1:150453465 - 150750307 on Build GRCh38	Gain	MIR4257 ADAMTSL4 MCL1 ECM1 ADAMTSL4-AS1 LOC107983947 RPRD2 GOLPH3L FALEC MIR6878 HORMAD1 CTSS LOC100289061 TARS2 ENSA

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate determination
multicellular organism development
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
cellular homeostasis
response to cytokine
negative regulation of apoptotic process
protein transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of anoikis
regulation of response to DNA damage stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

protein binding
protein channel activity
protein homodimerization activity
protein heterodimerization activity
BH3 domain binding