Hs03356254_cn

• Gene Symbol: PDE4B
• Assay Reference Genome Location: Chr.1:65803682 on build GRCh38
• Cytoband: 1p31.3

Target Gene Details

• Entrez Gene ID: 5142
• Gene Name: phosphodiesterase 4B
• Gene Aliases: DPDE4, PDEIVB
• Location: Chr.1:65792510-66374579 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PDE4B	NM_001037341.1			NP_001032418.1
	NM_001297440.1			NP_001284369.1
	NM_002600.3			NP_002591.2
	AK289969.1
	BC101480.1			AAI01481.1
	BC105040.1			AAI05041.1
	BF513098.1
	CR749667.1			CAH18458.2
	DA103627.1
	DA126733.1
	L20966.1			AAA03589.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv3n17	Chr.1:65756073 - 65806453 on Build GRCh38	Loss	PDE4B
nsv437216	Chr.1:65791733 - 65806453 on Build GRCh38	Loss	PDE4B

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

phosphodiesterase

Gene Ontology Categories:

Process(es)

neutrophil homeostasis
cAMP catabolic process
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
cellular response to drug
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
regulation of cardiac muscle cell contraction
regulation of high voltage-gated calcium channel activity
negative regulation of relaxation of cardiac muscle

Function(s)

3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
gamma-tubulin binding
ion channel binding
metal ion binding