Hs03416985_cn

• Gene Symbol: NCK2
• Assay Reference Genome Location: Chr.2:105755849 on build GRCh38
• Cytoband: 2q12.2

Target Gene Details

• Entrez Gene ID: 8440
• Gene Name: NCK adaptor protein 2
• Gene Aliases: GRB4, NCKbeta
• Location: Chr.2:105744649-105894274 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NCK2	NM_001004722.3			NP_001004722.1
	NM_003581.4			NP_003572.2
	XM_006712797.3			XP_006712860.1
	XM_011511991.2			XP_011510293.1
	XM_017005103.1			XP_016860592.1
	XM_017005105.1			XP_016860594.1
	BG480643.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834321	Chr.2:105663236 - 105841053 on Build GRCh38	Loss	NCK2
esv3591838	Chr.2:105752843 - 105763169 on Build GRCh38	Loss	NCK2
esv3591832	Chr.2:105718584 - 105763440 on Build GRCh38	Loss	NCK2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

immunological synapse formation
actin filament organization
signal transduction
signal complex assembly
epidermal growth factor receptor signaling pathway
regulation of epidermal growth factor-activated receptor activity
negative regulation of cell proliferation
vesicle-mediated transport
cell migration
lamellipodium assembly
positive regulation of actin filament polymerization
negative regulation of peptidyl-serine phosphorylation
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
dendritic spine development
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

SH3/SH2 adaptor activity
ARF guanyl-nucleotide exchange factor activity
protein binding
cytoskeletal adaptor activity
receptor signaling complex scaffold activity
protein complex binding
scaffold protein binding