Hs03467982_cn

• Gene Symbol: CRBN
• Assay Reference Genome Location: Chr.3:3161057 on build GRCh38
• Cytoband: 3p26.2

Target Gene Details

• Entrez Gene ID: 51185
• Gene Name: cereblon
• Gene Aliases: MRT2, MRT2A
• Location: Chr.3:3148490-3179717 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRBN	NM_001173482.1			NP_001166953.1
	NM_016302.3			NP_057386.2
	XM_005265202.3			XP_005265259.1
	XM_011533791.2			XP_011532093.1
	XM_011533793.2			XP_011532095.1
	XM_011533794.2			XP_011532096.1
	AF117230.1			AAF17211.1
	AK027507.1			BAB55162.1
	AK058191.1
	AK301423.1
	AK312577.1
	BC017419.1			AAH17419.1
	BC067811.1			AAH67811.1
	CR627060.1			CAH10361.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv589371	Chr.3:2170634 - 3594980 on Build GRCh38	Loss	CNTN4-AS1 CNTN4 CRBN LOC100130207 IL5RA TRNT1
esv2751994	Chr.3:2200757 - 3178886 on Build GRCh38	Gain	CNTN4-AS1 CNTN4 CRBN IL5RA TRNT1
esv2422274	Chr.3:2100396 - 3314907 on Build GRCh38	Duplication	CNTN4-AS1 CNTN4-AS2 CNTN4 CRBN LOC100130207 IL5RA TRNT1
dgv4636n100	Chr.3:2825734 - 3271845 on Build GRCh38	Gain	CNTN4-AS1 CNTN4 CRBN LOC100130207 IL5RA TRNT1
nsv834604	Chr.3:3147083 - 3361983 on Build GRCh38	Gain	CRBN LOC100130207 TRNT1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease, ubiquitin-protein ligase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

protein ubiquitination
negative regulation of protein homooligomerization
negative regulation of ion transmembrane transport
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein homodimerization activity

Function(s)

ATP-dependent peptidase activity
protein binding
metal ion binding