Hs03546626_cn

• Gene Symbol: DHFR
• Assay Reference Genome Location: Chr.5:80630680 on build GRCh38
• Cytoband: 5q14.1

Target Gene Details

• Entrez Gene ID: 1719
• Gene Name: dihydrofolate reductase
• Gene Aliases: DHFRP1, DYR
• Location: Chr.5:80626226-80654981 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DHFR	NM_000791.3			NP_000782.1
	NM_001290354.1			NP_001277283.1
	NM_001290357.1			NP_001277286.1
	NR_110936.1
	AK293146.1
	AK297302.1
	AK308492.1
	BC000192.1			AAH00192.1
	BC003584.1			AAH03584.2
	BC070280.1			AAH70280.1
	BC071996.1			AAH71996.1
	J00140.1			AAA58485.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv483112	Chr.5:80551019 - 80731514 on Build GRCh38	Loss	MTRNR2L2 DHFR ANKRD34B MSH3 LINC01337
nsv4895	Chr.5:80623591 - 80640149 on Build GRCh38	Insertion	DHFR

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

reductase

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
glycine biosynthetic process
tetrahydrobiopterin biosynthetic process
one-carbon metabolic process
nucleotide biosynthetic process
axon regeneration
response to methotrexate
dihydrofolate metabolic process
tetrahydrofolate metabolic process
tetrahydrofolate biosynthetic process
folic acid metabolic process
positive regulation of nitric-oxide synthase activity
oxidation-reduction process
regulation of removal of superoxide radicals

Function(s)

mRNA binding
dihydrofolate reductase activity
folic acid binding
drug binding
folate reductase activity
methotrexate binding
NADPH binding