Hs03629005_cn

• Gene Symbol: SRPK2
• Assay Reference Genome Location: Chr.7:105121882 on build GRCh38
• Cytoband: 7q22.3

Target Gene Details

• Entrez Gene ID: 6733
• Gene Name: SRSF protein kinase 2
• Gene Aliases: SFRSK2
• Location: Chr.7:105110708-105399366 on Build GRCh38
• Assay Gene Location: Within Intron 21

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SRPK2	NM_001278273.1			NP_001265202.1
	NM_182691.2			NP_872633.1
	NM_182692.2			NP_872634.1
	XM_005250549.3			XP_005250606.2
	XM_005250550.3			XP_005250607.1
	XM_005250551.4			XP_005250608.1
	XM_006716098.2			XP_006716161.1
	XM_011516536.2			XP_011514838.1
	XM_011516538.2			XP_011514840.1
	XM_017012560.1			XP_016868049.1
	XM_017012561.1			XP_016868050.1
	XM_017012562.1			XP_016868051.1
	XM_017012563.1			XP_016868052.1
	XM_017012564.1			XP_016868053.1
	XM_017012565.1			XP_016868054.1
	XM_017012566.1			XP_016868055.1
	AK093420.1
	AY354201.1			AAQ63886.1
	BC035214.1			AAH35214.1
	BC068547.1			AAH68547.1
	U88666.1			AAC05299.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv237e55	Chr.7:105097165 - 105512795 on Build GRCh38	Gain	SRPK2 PUS7 KMT2E
esv2759549	Chr.7:105117803 - 105568045 on Build GRCh38	Gain	SRPK2 EFCAB10 PUS7 RINT1
nsv436902	Chr.7:104802439 - 105205347 on Build GRCh38	Insertion	LHFPL3-AS2 LHFPL3-AS1 LINC01004 SRPK2 LOC101927902 KMT2E-AS1 KMT2E LHFPL3

More Information

Additional Information:

For this assay, SNP(s) [rs143667356] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

spliceosomal complex assembly
angiogenesis
protein phosphorylation
positive regulation of cell proliferation
RNA splicing
positive regulation of gene expression
cell differentiation
nuclear speck organization
intracellular signal transduction
positive regulation of neuron apoptotic process
positive regulation of viral genome replication
negative regulation of viral genome replication
innate immune response
positive regulation of cell cycle
regulation of mRNA splicing, via spliceosome

Function(s)

magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
poly(A) RNA binding
14-3-3 protein binding