Hs03658333_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144073927 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	FOXH1 TONSL MIR6893 ADCK5 LRRC14 DGAT1 MIR6846 MFSD3 HSF1 PARP10 CYHR1 RECQL4 WDR97 TONSL-AS1 MIR661 MIR6848 EXOSC4 HGH1 LOC101928902 KIFC2 SLC52A2 PLEC CYC1 SHARPIN VPS28 MIR6849 FBXL6 MIR7112 OPLAH GPT MIR1234 GPAA1 MIR6847 SCX CPSF1 SCRT1 MROH1 MIR939 SLC39A4 PPP1R16A MAF1 TMEM249 LOC101928953 BOP1 GRINA SPATC1 SMPD5
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	GPAA1 MIR6847 MIR6846 PARP10 WDR97 EXOSC4 PLEC CYC1 SHARPIN MAF1 OPLAH GRINA SPATC1 SMPD5
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	GPAA1 MIR6847 EPPK1 MIR6846 PARP10 WDR97 MIR661 EXOSC4 PLEC CYC1 SHARPIN MAF1 OPLAH GRINA SPATC1 SMPD5
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR937 MIR6847 LOC642574 EPPK1 PUF60 MIR6846 PARP10 MIR6845 MIR661 EXOSC4 NRBP2 PLEC OPLAH GRINA SPATC1 SCRIB SMPD5
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	GPAA1 MIR6847 SCX MIR6846 HSF1 WDR97 EXOSC4 HGH1 MROH1 CYC1 SHARPIN MAF1 MIR7112 OPLAH BOP1 SPATC1 SMPD5
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	GPAA1 HGH1 MIR6847 MROH1 CYC1 SHARPIN MAF1 WDR97 EXOSC4
nsv612915	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	GPAA1 MIR6847 MIR6846 WDR97 EXOSC4 HGH1 MROH1 CYC1 SHARPIN MAF1 OPLAH SPATC1 SMPD5
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	GPAA1 MIR6847 EXOSC4
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	FOXH1 TONSL MIR6893 ADCK5 LRRC14 DGAT1 MIR6846 MFSD3 HSF1 PARP10 CYHR1 RECQL4 WDR97 TONSL-AS1 MIR661 MIR6848 EXOSC4 HGH1 LOC101928902 KIFC2 SLC52A2 PLEC CYC1 SHARPIN VPS28 MIR6849 FBXL6 MIR7112 OPLAH GPT MIR1234 GPAA1 MIR6847 SCX CPSF1 SCRT1 MROH1 MIR939 SLC39A4 PPP1R16A MAF1 TMEM249 LOC101928953 BOP1 GRINA SPATC1 SMPD5
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	GPAA1 MIR6847 EPPK1 MIR6846 PARP10 WDR97 MIR661 EXOSC4 HGH1 MROH1 PLEC CYC1 SHARPIN MAF1 OPLAH GRINA SPATC1 SMPD5
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	C8orf82 FOXH1 TONSL MIR6893 ADCK5 LRRC14 DGAT1 MIR6846 MFSD3 HSF1 CYHR1 RECQL4 WDR97 TONSL-AS1 MIR6848 EXOSC4 ARHGAP39 HGH1 LOC101928902 KIFC2 SLC52A2 CYC1 SHARPIN VPS28 MIR6849 FBXL6 MIR7112 OPLAH GPT MIR1234 GPAA1 MIR6847 SCX LRRC24 CPSF1 SCRT1 ZNF251 MROH1 MIR939 SLC39A4 PPP1R16A MAF1 TMEM249 LOC101928953 BOP1 SPATC1 SMPD5
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	GPAA1 MIR6847 PLEC CYC1 MIR6846 PARP10 OPLAH GRINA MIR661 SPATC1 SMPD5 EXOSC4
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	GPAA1 MIR6847 MIR6846 PARP10 WDR97 MIR661 EXOSC4 PLEC CYC1 SHARPIN MAF1 OPLAH GRINA SPATC1 SMPD5
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	GPAA1 MIR6847 PLEC MIR6846 PARP10 OPLAH GRINA MIR661 SPATC1 SMPD5 EXOSC4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding