Hs03786585_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:415972 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	MIR210HG LMNTD2 IRF7 HRAS LRRC56 IFITM5 LOC101059906 PKP3 PHRF1 IFITM2 PGGHG LOC143666 ANO9 B4GALNT4 IFITM3 CDHR5 SIGIRR IFITM1 MIR210 PTDSS2 RASSF7 RNH1
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	MIR210HG LMNTD2 HRAS LRRC56 MUC5B LOC101059906 PANO1 LOC171391 SCT SLC25A22 ANO9 B4GALNT4 POLR2L SIGIRR MUC5AC EPS8L2 AP2A2 TOLLIP MIR210 CEND1 TALDO1 DRD4 CD151 PDDC1 TMEM80 IRF7 MIR6744 PIDD1 PKP3 LOC101927503 SNORA52 CHID1 PHRF1 LOC143666 TSPAN4 DEAF1 CDHR5 MUC6 PNPLA2 CRACR2B MUC2 PTDSS2 RASSF7 RNH1 RPLP2
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	ANO9 B4GALNT4 SIGIRR PKP3
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	ANO9 SIGIRR
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	ANO9 SIGIRR
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	MIR210HG LMNTD2 HRAS LRRC56 MUC5B LOC101059906 PANO1 LOC171391 SCT SLC25A22 ANO9 POLR2L SIGIRR MUC5AC EPS8L2 AP2A2 TOLLIP MIR210 CEND1 TALDO1 DRD4 CD151 PDDC1 TMEM80 IRF7 MIR6744 PIDD1 LOC101927503 SNORA52 CHID1 PHRF1 LOC143666 TOLLIP-AS1 TSPAN4 DEAF1 CDHR5 MUC6 PNPLA2 CRACR2B MUC2 PTDSS2 RASSF7 RNH1 RPLP2
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	ANO9 SIGIRR
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	ANO9 B4GALNT4 SIGIRR PKP3 PTDSS2 RNH1
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	ANO9 B4GALNT4 SIGIRR PKP3
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	IFITM5 PKP3 IFITM2 PGGHG ANO9 SIRT3 B4GALNT4 IFITM3 SIGIRR MIR6743 RIC8A IFITM1 NLRP6 PTDSS2 PSMD13 ODF3 BET1L
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	ANO9 B4GALNT4 SIGIRR PKP3 PTDSS2
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	MIR210HG LMNTD2 HRAS LRRC56 LOC101059906 PANO1 LOC171391 SCT SLC25A22 ANO9 B4GALNT4 POLR2L SIGIRR EPS8L2 AP2A2 MIR210 CEND1 TALDO1 DRD4 CD151 PDDC1 TMEM80 IRF7 PIDD1 PKP3 SNORA52 CHID1 PHRF1 LOC143666 TSPAN4 DEAF1 CDHR5 PNPLA2 CRACR2B PTDSS2 RASSF7 RNH1 RPLP2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding