Hs03808186_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57519743 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MIR6758 INHBC DDIT3 MARS PIP4K2C ARHGAP9 KIF5A MBD6 INHBE DCTN2 DTX3 MIR616 GLI1
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	MIR6758 LOC101927583 DDIT3 MARS PIP4K2C ARHGAP9 ARHGEF25 KIF5A MBD6 DCTN2 DTX3 MIR616 GLI1
nsv469411	Chr.12:57450266 - 57527405 on Build GRCh38	Loss	MIR6758 INHBC MBD6 INHBE DDIT3 MARS ARHGAP9 MIR616 GLI1
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MBD6 DDIT3 MIR616
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	STAC3 PRIM1 ATP5B INHBC LRP1-AS IL23A PIP4K2C ARHGAP9 STAT6 SNORA105C STAT2 RDH16 CNPY2 MIR1228 NAB2 CS SHMT2 SNORD59A ANKRD52 DDIT3 RBMS2 PAN2 APOF RNF41 SLC26A10 NABP2 MBD6 DCTN2 HSD17B6 MYO1A DTX3 NXPH4 ZBTB39 HBCBP PTGES3 MIP LRP1 B4GALNT1 BAZ2A ARHGEF25 TAC3 SLC39A5 TIMELESS NACA KIF5A NDUFA4L2 SNORD59B SPRYD4 MIR616 R3HDM2 MIR6758 LOC101927583 GPR182 MARS SDR9C7 NEMP1 COQ10A INHBE OS9 GLS2 GLI1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity