Hs04012521_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1211826 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	C19orf24 ARHGAP45 GPX4 SBNO2 ABCA7 POLR2E STK11 EFNA2 CBARP CIRBP-AS1 CIRBP ATP5D MIDN LOC102725180
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	C19orf24 ARHGAP45 GPX4 SBNO2 ABCA7 POLR2E STK11 EFNA2 CBARP CNN2 CIRBP-AS1 CIRBP ATP5D MIDN LOC102725180
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	C19orf24 ARHGAP45 GPX4 SBNO2 RNU6-2 ABCA7 POLR2E RNU6-9 STK11 ARID3A TMEM259 EFNA2 CBARP GRIN3B CNN2 KISS1R R3HDM4 WDR18 CIRBP-AS1 CIRBP LOC105372235 ATP5D MIDN LOC102725180
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	C19orf24 SBNO2 STK11 CIRBP-AS1 CIRBP ATP5D MIDN LOC102725180 EFNA2 CBARP
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	SBNO2 ARID3A TMEM259 MED16 EFNA2 CBARP CNN2 KISS1R WDR18 CIRBP-AS1 MIDN C19orf24 ARHGAP45 GPX4 RNU6-2 ABCA7 POLR2E RNU6-9 STK11 GRIN3B R3HDM4 CIRBP LOC105372235 ATP5D LOC102725180
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	C19orf24 STK11 CIRBP-AS1 CIRBP ATP5D MIDN EFNA2 CBARP
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	C19orf24 ARHGAP45 GPX4 SBNO2 POLR2E STK11 EFNA2 CBARP CIRBP-AS1 CIRBP ATP5D MIDN LOC102725180
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	SBNO2 ARID3A NDUFS7 PCSK4 TMEM259 RPS15 EFNA2 CBARP MUM1 CNN2 WDR18 CIRBP-AS1 PLK5 MIDN ADAMTSL5 C19orf24 ARHGAP45 GPX4 APC2 DAZAP1 RNU6-2 ABCA7 POLR2E STK11 GRIN3B REEP6 C19orf25 GAMT CIRBP LOC105372235 ATP5D LOC102725180

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity