Hs04013006_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1220256 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	C19orf24 STK11 MIDN POLR2E CIRBP-AS1 LOC102725180 SBNO2 ATP5D GPX4 EFNA2 CIRBP ABCA7 CBARP ARHGAP45
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	C19orf24 STK11 MIDN POLR2E CIRBP-AS1 LOC102725180 SBNO2 ATP5D GPX4 EFNA2 CIRBP ABCA7 CBARP CNN2 ARHGAP45
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	C19orf24 STK11 MIDN POLR2E CIRBP-AS1 ARID3A LOC105372235 LOC102725180 TMEM259 KISS1R SBNO2 ATP5D GPX4 EFNA2 WDR18 CIRBP ABCA7 GRIN3B R3HDM4 CBARP RNU6-2 RNU6-9 CNN2 ARHGAP45
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	ATP5D C19orf24 STK11 EFNA2 MIDN CIRBP CIRBP-AS1 CBARP LOC102725180 SBNO2
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	MED16 CIRBP-AS1 LOC102725180 KISS1R ATP5D CIRBP RNU6-2 RNU6-9 CNN2 ARHGAP45 C19orf24 STK11 MIDN POLR2E ARID3A LOC105372235 TMEM259 SBNO2 GPX4 EFNA2 WDR18 ABCA7 GRIN3B R3HDM4 CBARP
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	ATP5D C19orf24 STK11 EFNA2 MIDN CIRBP CIRBP-AS1 CBARP
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	C19orf24 STK11 MIDN POLR2E CIRBP-AS1 LOC102725180 SBNO2 ATP5D GPX4 EFNA2 CIRBP CBARP ARHGAP45
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	MUM1 C19orf25 CIRBP-AS1 GAMT LOC102725180 NDUFS7 ATP5D PCSK4 REEP6 CIRBP RNU6-2 CNN2 ARHGAP45 PLK5 DAZAP1 C19orf24 STK11 MIDN RPS15 POLR2E ARID3A LOC105372235 TMEM259 SBNO2 GPX4 EFNA2 WDR18 ADAMTSL5 ABCA7 GRIN3B CBARP APC2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity