Hs04016216_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1220925 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	MIDN ARHGAP45 CIRBP-AS1 STK11 CBARP SBNO2 POLR2E CIRBP LOC102725180 ABCA7 ATP5D EFNA2 GPX4 C19orf24
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	MIDN ARHGAP45 CIRBP-AS1 STK11 CNN2 CBARP SBNO2 POLR2E CIRBP LOC102725180 ABCA7 ATP5D EFNA2 GPX4 C19orf24
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	LOC105372235 MIDN RNU6-9 ARID3A ARHGAP45 CIRBP-AS1 STK11 CNN2 CBARP WDR18 RNU6-2 SBNO2 POLR2E GRIN3B CIRBP LOC102725180 ABCA7 TMEM259 ATP5D KISS1R EFNA2 R3HDM4 GPX4 C19orf24
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	MIDN CIRBP LOC102725180 CIRBP-AS1 STK11 CBARP ATP5D EFNA2 C19orf24 SBNO2
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	MIDN ARHGAP45 CIRBP-AS1 STK11 CNN2 CBARP WDR18 RNU6-2 SBNO2 POLR2E CIRBP ABCA7 TMEM259 EFNA2 C19orf24 LOC105372235 RNU6-9 ARID3A GRIN3B LOC102725180 ATP5D KISS1R R3HDM4 GPX4 MED16
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	MIDN CIRBP CIRBP-AS1 STK11 CBARP ATP5D EFNA2 C19orf24
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	MIDN ARHGAP45 CIRBP-AS1 STK11 CBARP SBNO2 POLR2E CIRBP LOC102725180 ATP5D EFNA2 GPX4 C19orf24
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	MIDN ARHGAP45 CIRBP-AS1 STK11 CNN2 NDUFS7 CBARP WDR18 PLK5 RNU6-2 PCSK4 SBNO2 POLR2E CIRBP ABCA7 TMEM259 EFNA2 C19orf24 REEP6 LOC105372235 DAZAP1 GAMT ARID3A RPS15 APC2 ADAMTSL5 GRIN3B LOC102725180 ATP5D GPX4 C19orf25 MUM1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity