Hs04023057_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1218606 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	LOC102725180 EFNA2 STK11 GPX4 ATP5D CIRBP CIRBP-AS1 C19orf24 SBNO2 ABCA7 MIDN POLR2E CBARP ARHGAP45
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	LOC102725180 EFNA2 CNN2 STK11 GPX4 ATP5D CIRBP CIRBP-AS1 C19orf24 SBNO2 ABCA7 MIDN POLR2E CBARP ARHGAP45
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	LOC102725180 EFNA2 CNN2 STK11 KISS1R GPX4 ATP5D CIRBP CIRBP-AS1 RNU6-2 ARID3A TMEM259 GRIN3B C19orf24 SBNO2 ABCA7 MIDN RNU6-9 POLR2E R3HDM4 CBARP WDR18 LOC105372235 ARHGAP45
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	LOC102725180 EFNA2 STK11 C19orf24 SBNO2 MIDN ATP5D CIRBP CIRBP-AS1 CBARP
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	LOC102725180 STK11 GPX4 ATP5D RNU6-2 ARID3A TMEM259 GRIN3B SBNO2 MED16 POLR2E R3HDM4 CBARP WDR18 LOC105372235 EFNA2 CNN2 KISS1R CIRBP CIRBP-AS1 C19orf24 ABCA7 MIDN RNU6-9 ARHGAP45
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	EFNA2 STK11 C19orf24 MIDN ATP5D CIRBP CIRBP-AS1 CBARP
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	LOC102725180 EFNA2 STK11 GPX4 ATP5D CIRBP CIRBP-AS1 C19orf24 SBNO2 MIDN POLR2E CBARP ARHGAP45
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	LOC102725180 STK11 GPX4 ATP5D RNU6-2 NDUFS7 ARID3A TMEM259 MUM1 GRIN3B APC2 PCSK4 SBNO2 GAMT POLR2E PLK5 CBARP WDR18 LOC105372235 RPS15 C19orf25 EFNA2 CNN2 CIRBP CIRBP-AS1 DAZAP1 REEP6 ADAMTSL5 C19orf24 ABCA7 MIDN ARHGAP45

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity