Hs04024995_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1214601 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	POLR2E CIRBP C19orf24 LOC102725180 CIRBP-AS1 GPX4 EFNA2 SBNO2 ATP5D MIDN ARHGAP45 STK11 ABCA7 CBARP
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	POLR2E CIRBP CNN2 C19orf24 LOC102725180 CIRBP-AS1 GPX4 EFNA2 SBNO2 ATP5D MIDN ARHGAP45 STK11 ABCA7 CBARP
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	POLR2E CIRBP CNN2 C19orf24 WDR18 RNU6-2 ARID3A LOC102725180 RNU6-9 CIRBP-AS1 R3HDM4 GPX4 TMEM259 KISS1R EFNA2 GRIN3B SBNO2 ATP5D MIDN ARHGAP45 STK11 LOC105372235 ABCA7 CBARP
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	CIRBP EFNA2 C19orf24 SBNO2 ATP5D MIDN LOC102725180 CIRBP-AS1 STK11 CBARP
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	POLR2E CNN2 WDR18 RNU6-2 LOC102725180 RNU6-9 CIRBP-AS1 GPX4 EFNA2 GRIN3B ATP5D LOC105372235 ABCA7 CIRBP C19orf24 ARID3A R3HDM4 MED16 TMEM259 KISS1R SBNO2 MIDN ARHGAP45 STK11 CBARP
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	CIRBP EFNA2 C19orf24 ATP5D MIDN CIRBP-AS1 STK11 CBARP
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	POLR2E CIRBP C19orf24 LOC102725180 CIRBP-AS1 GPX4 EFNA2 SBNO2 ATP5D MIDN ARHGAP45 STK11 CBARP
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	POLR2E CNN2 GAMT WDR18 RNU6-2 APC2 LOC102725180 CIRBP-AS1 NDUFS7 GPX4 MUM1 PCSK4 EFNA2 GRIN3B ATP5D C19orf25 LOC105372235 ABCA7 CIRBP REEP6 C19orf24 ADAMTSL5 RPS15 ARID3A PLK5 TMEM259 DAZAP1 SBNO2 MIDN ARHGAP45 STK11 CBARP

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity