Hs04027172_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1218317 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	SBNO2 ARHGAP45 STK11 CBARP C19orf24 MIDN GPX4 ATP5D CIRBP-AS1 POLR2E LOC102725180 ABCA7 EFNA2 CIRBP
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	SBNO2 ARHGAP45 STK11 CBARP C19orf24 CNN2 MIDN GPX4 ATP5D CIRBP-AS1 POLR2E LOC102725180 ABCA7 EFNA2 CIRBP
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	SBNO2 ARHGAP45 STK11 KISS1R LOC105372235 RNU6-9 CBARP TMEM259 R3HDM4 C19orf24 CNN2 MIDN GPX4 ATP5D GRIN3B CIRBP-AS1 POLR2E LOC102725180 ABCA7 EFNA2 WDR18 ARID3A RNU6-2 CIRBP
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	SBNO2 LOC102725180 STK11 CBARP EFNA2 C19orf24 MIDN ATP5D CIRBP CIRBP-AS1
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	KISS1R CBARP MED16 C19orf24 ATP5D POLR2E LOC102725180 ABCA7 EFNA2 ARID3A RNU6-2 SBNO2 ARHGAP45 STK11 LOC105372235 RNU6-9 TMEM259 R3HDM4 CNN2 MIDN GPX4 GRIN3B CIRBP-AS1 WDR18 CIRBP
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	STK11 CBARP EFNA2 C19orf24 MIDN ATP5D CIRBP CIRBP-AS1
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	SBNO2 ARHGAP45 STK11 CBARP C19orf24 MIDN GPX4 ATP5D CIRBP-AS1 POLR2E LOC102725180 EFNA2 CIRBP
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	RPS15 CBARP C19orf24 APC2 ATP5D REEP6 POLR2E MUM1 LOC102725180 ABCA7 EFNA2 ARID3A GAMT RNU6-2 C19orf25 DAZAP1 SBNO2 ARHGAP45 STK11 LOC105372235 PLK5 TMEM259 PCSK4 CNN2 MIDN GPX4 GRIN3B CIRBP-AS1 NDUFS7 WDR18 ADAMTSL5 CIRBP

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity