Hs04086803_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20080853 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1			NP_001177255.1
	NM_022720.6			NP_073557.3
	AK313357.1
	BC009984.2			AAH09984.1
	BQ227899.1
	DA433651.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	CCDC188 MIR6816 LINC00896 MIR1286 MIR3618 MIR1306 TRMT2A DGCR6L RANBP1 DGCR8 LOC284865 LOC440792 ZDHHC8 RTN4R
dgv7985n54	Chr.22:20042355 - 20084214 on Build GRCh38	Loss	DGCR8 TANGO2
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	DGCR8 MIR6816 ZDHHC8 ARVCF MIR3618 MIR1306 TANGO2 MIR185 TRMT2A RANBP1
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	CCDC188 GNB1L MIR6816 UFD1L GP1BB MIR1286 MIR4761 TANGO2 MIR185 DGCR6L RANBP1 C22orf29 RTN4R LOC101927859 SEPT5-GP1BB SEPT5 COMT LINC00896 TXNRD2 MIR3618 MIR1306 TRMT2A CDC45 LINC00895 DGCR8 LOC284865 TBX1 LOC440792 ZDHHC8 ARVCF CLDN5
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	CCDC188 MIR6816 LINC00896 MIR1286 MIR3618 MIR1306 TANGO2 TRMT2A DGCR6L RANBP1 DGCR8 LOC284865 LOC440792 ZDHHC8 RTN4R
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	CCDC188 GNB1L MIR6816 GP1BB MIR1286 MIR4761 TANGO2 MIR185 DGCR6L RANBP1 C22orf29 RTN4R SEPT5-GP1BB SEPT5 COMT LINC00896 TXNRD2 MIR3618 MIR1306 TRMT2A DGCR8 LOC284865 TBX1 LOC440792 ZDHHC8 ARVCF
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	CCDC188 GNB1L MIR6816 GP1BB MIR1286 MIR4761 TANGO2 MIR185 DGCR6L RANBP1 C22orf29 RTN4R SEPT5-GP1BB SEPT5 COMT LINC00896 TXNRD2 MIR3618 MIR1306 TRMT2A DGCR8 LOC284865 TBX1 LOC440792 ZDHHC8 ARVCF
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	CCDC188 DGCR8 LOC284865 MIR6816 LINC00896 ZDHHC8 MIR1286 MIR3618 MIR1306 RTN4R TRMT2A RANBP1
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	CCDC188 MIR6816 LINC00896 MIR1286 MIR3618 MIR1306 TANGO2 MIR185 TRMT2A DGCR6L RANBP1 DGCR8 LOC284865 LOC440792 ZDHHC8 RTN4R
dgv72n68	Chr.22:19891663 - 20082447 on Build GRCh38	Loss	DGCR8 TXNRD2 ARVCF MIR4761 TANGO2 MIR185 COMT
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	CCDC188 DGCR8 MIR6816 ZDHHC8 MIR3618 MIR1306 TANGO2 MIR185 TRMT2A RANBP1
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	CCDC188 GNB1L MIR6816 LINC00896 TXNRD2 MIR1286 MIR4761 MIR3618 MIR1306 TANGO2 MIR185 TRMT2A DGCR6L RANBP1 DGCR8 LOC284865 TBX1 LOC440792 ZDHHC8 ARVCF C22orf29 RTN4R COMT

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding