Hs04091056_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20088423 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1			NP_001177255.1
	NM_022720.6			NP_073557.3
	AK025539.1			BAB15165.1
	AK222796.1			BAD96516.1
	AK313357.1
	BC009323.2			AAH09323.2
	BC009984.2			AAH09984.1
	BC078147.1			AAH78147.1
	BX649187.1			CAE46205.2
	CR456356.1			CAG30242.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	LOC440792 RTN4R RANBP1 MIR6816 ZDHHC8 MIR3618 CCDC188 LOC284865 MIR1286 DGCR8 DGCR6L MIR1306 LINC00896 TRMT2A
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	ARVCF DGCR8 TANGO2 MIR185 RANBP1 MIR1306 MIR6816 ZDHHC8 MIR3618 TRMT2A
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	LOC440792 RTN4R UFD1L C22orf29 SEPT5-GP1BB ZDHHC8 GNB1L DGCR8 DGCR6L LOC101927859 TXNRD2 TRMT2A TANGO2 MIR185 RANBP1 MIR6816 MIR3618 CCDC188 CLDN5 COMT LOC284865 MIR4761 GP1BB ARVCF MIR1286 SEPT5 TBX1 LINC00895 CDC45 MIR1306 LINC00896
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	LOC440792 RTN4R TANGO2 RANBP1 MIR6816 ZDHHC8 MIR3618 CCDC188 LOC284865 MIR1286 DGCR8 DGCR6L MIR1306 LINC00896 TRMT2A
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	LOC440792 RTN4R C22orf29 SEPT5-GP1BB ZDHHC8 GNB1L DGCR8 DGCR6L TXNRD2 TRMT2A TANGO2 MIR185 RANBP1 MIR6816 MIR3618 CCDC188 COMT LOC284865 MIR4761 GP1BB ARVCF MIR1286 SEPT5 TBX1 MIR1306 LINC00896
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	LOC440792 RTN4R C22orf29 SEPT5-GP1BB ZDHHC8 GNB1L DGCR8 DGCR6L TXNRD2 TRMT2A TANGO2 MIR185 RANBP1 MIR6816 MIR3618 CCDC188 COMT LOC284865 MIR4761 GP1BB ARVCF MIR1286 SEPT5 TBX1 MIR1306 LINC00896
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	LOC284865 MIR1286 RTN4R DGCR8 RANBP1 MIR1306 MIR6816 LINC00896 ZDHHC8 MIR3618 CCDC188 TRMT2A
dgv1291e212	Chr.22:20088151 - 20092050 on Build GRCh38	Loss	DGCR8
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	LOC440792 RTN4R TANGO2 MIR185 RANBP1 MIR6816 ZDHHC8 MIR3618 CCDC188 LOC284865 MIR1286 DGCR8 DGCR6L MIR1306 LINC00896 TRMT2A
nsv953027	Chr.22:20085378 - 20303977 on Build GRCh38	Deletion	LOC440792 RTN4R RANBP1 MIR6816 ZDHHC8 MIR3618 CCDC188 LOC284865 MIR1286 DGCR8 MIR1306 LINC00896 TRMT2A
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	DGCR8 TANGO2 MIR185 RANBP1 MIR1306 MIR6816 ZDHHC8 MIR3618 CCDC188 TRMT2A
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	LOC440792 RTN4R TANGO2 MIR185 RANBP1 C22orf29 MIR6816 ZDHHC8 MIR3618 CCDC188 COMT LOC284865 MIR4761 GNB1L ARVCF MIR1286 DGCR8 TBX1 DGCR6L MIR1306 LINC00896 TXNRD2 TRMT2A

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding