Hs04358724_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144070888 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	BOP1 MFSD3 HSF1 PPP1R16A SPATC1 MIR6893 GPAA1 MIR1234 MIR6847 MAF1 SHARPIN CYC1 MROH1 MIR6849 HGH1 SLC39A4 LOC101928953 TMEM249 VPS28 MIR7112 EXOSC4 SLC52A2 ADCK5 MIR6848 DGAT1 GRINA MIR939 SMPD5 OPLAH PLEC MIR661 SCRT1 TONSL GPT RECQL4 LOC101928902 PARP10 WDR97 SCX CYHR1 CPSF1 FBXL6 MIR6846 TONSL-AS1 LRRC14 FOXH1 KIFC2
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SPATC1 GRINA GPAA1 SMPD5 OPLAH PLEC MIR6847 MAF1 SHARPIN PARP10 WDR97 CYC1 MIR6846 EXOSC4
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	SPATC1 GRINA GPAA1 SMPD5 OPLAH PLEC MIR661 MIR6847 MAF1 SHARPIN PARP10 WDR97 CYC1 MIR6846 EPPK1 EXOSC4
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	SPATC1 PUF60 GRINA MIR937 SMPD5 OPLAH PLEC MIR661 MIR6847 PARP10 NRBP2 SCRIB MIR6846 MIR6845 LOC642574 EPPK1 EXOSC4
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	BOP1 HSF1 SPATC1 GPAA1 SMPD5 OPLAH MIR6847 MAF1 SHARPIN WDR97 CYC1 SCX MROH1 HGH1 MIR6846 MIR7112 EXOSC4
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	MIR6847 MAF1 SHARPIN WDR97 CYC1 MROH1 HGH1 GPAA1 EXOSC4
nsv612915	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	SPATC1 GPAA1 SMPD5 OPLAH MIR6847 MAF1 SHARPIN WDR97 CYC1 MROH1 HGH1 MIR6846 EXOSC4
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	MIR6847 GPAA1 EXOSC4
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	BOP1 MFSD3 HSF1 PPP1R16A SPATC1 MIR6893 GPAA1 MIR1234 MIR6847 MAF1 SHARPIN CYC1 MROH1 MIR6849 HGH1 SLC39A4 LOC101928953 TMEM249 VPS28 MIR7112 EXOSC4 SLC52A2 ADCK5 MIR6848 DGAT1 GRINA MIR939 SMPD5 OPLAH PLEC MIR661 SCRT1 TONSL GPT RECQL4 LOC101928902 PARP10 WDR97 SCX CYHR1 CPSF1 FBXL6 MIR6846 TONSL-AS1 LRRC14 FOXH1 KIFC2
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	SPATC1 GRINA GPAA1 SMPD5 OPLAH PLEC MIR661 MIR6847 MAF1 SHARPIN PARP10 WDR97 CYC1 MROH1 HGH1 MIR6846 EPPK1 EXOSC4
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	BOP1 MFSD3 HSF1 PPP1R16A SPATC1 MIR6893 GPAA1 MIR1234 ARHGAP39 MIR6847 MAF1 SHARPIN LRRC24 CYC1 MROH1 MIR6849 HGH1 SLC39A4 LOC101928953 TMEM249 VPS28 MIR7112 EXOSC4 SLC52A2 ADCK5 MIR6848 DGAT1 MIR939 SMPD5 OPLAH SCRT1 TONSL GPT RECQL4 LOC101928902 WDR97 SCX C8orf82 CYHR1 CPSF1 FBXL6 MIR6846 ZNF251 TONSL-AS1 LRRC14 FOXH1 KIFC2
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	MIR6847 PARP10 SPATC1 CYC1 GRINA MIR6846 GPAA1 SMPD5 OPLAH PLEC MIR661 EXOSC4
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SPATC1 GRINA GPAA1 SMPD5 OPLAH PLEC MIR661 MIR6847 MAF1 SHARPIN PARP10 WDR97 CYC1 MIR6846 EXOSC4
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	MIR6847 PARP10 SPATC1 GRINA MIR6846 GPAA1 SMPD5 OPLAH PLEC MIR661 EXOSC4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding