Hs04388725_cn

• Gene Symbol: POLD3
• Assay Reference Genome Location: Chr.11:74606531 on build GRCh38
• Cytoband: 11q13.4

Target Gene Details

• Entrez Gene ID: 10714
• Gene Name: DNA polymerase delta 3, accessory subunit
• Gene Aliases: P66, P68, PPP1R128
• Location: Chr.11:74592530-74669341 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
POLD3	NM_006591.2			NP_006582.1
	NR_046409.1
	NR_046410.1
	XM_005273716.1			XP_005273773.1
	XM_011544734.2			XP_011543036.1
	AK302677.1
	AK316301.1
	AK316370.1
	BC032636.1
	BC092454.1			AAH92454.1
	BC108908.1			AAI08909.1
	BC108909.1			AAI08910.1
	D26018.1
	DC402448.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv34979	Chr.11:74167643 - 74822407 on Build GRCh38	Gain	KCNE3 PPME1 CHRDL2 C2CD3 LIPT2 PGM2L1 LOC101928580 P4HA3 POLD3 RNF169 MIR548AL MIR4696 LOC100287896
esv2759837	Chr.11:74131564 - 74846552 on Build GRCh38	Gain	KCNE3 PPME1 CHRDL2 XRRA1 C2CD3 LIPT2 PGM2L1 LOC101928580 P4HA3 POLD3 RNF169 MIR548AL MIR4696 LOC100287896
nsv832209	Chr.11:74444838 - 74618074 on Build GRCh38	Gain	LIPT2 KCNE3 POLD3 LOC100287896
dgv209e214	Chr.11:74225600 - 74828943 on Build GRCh38	Gain	LIPT2 PGM2L1 LOC101928580 P4HA3 KCNE3 POLD3 RNF169 PPME1 CHRDL2 MIR548AL MIR4696 LOC100287896
nsv825994	Chr.11:74225622 - 74823410 on Build GRCh38	Gain	LIPT2 PGM2L1 LOC101928580 P4HA3 KCNE3 POLD3 RNF169 PPME1 CHRDL2 MIR548AL MIR4696 LOC100287896

More Information

Additional Information:

For this assay, SNP(s) [rs116546781] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

telomere maintenance via recombination
telomere maintenance
DNA synthesis involved in DNA repair
DNA strand elongation involved in DNA replication
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
mismatch repair
translesion synthesis
nucleotide-excision repair, DNA incision
DNA damage response, detection of DNA damage

Function(s)

DNA-directed DNA polymerase activity
protein binding