Hs04449359_cn

• Gene Symbol: SPPL2A
• Assay Reference Genome Location: Chr.15:50705659 on build GRCh38
• Cytoband: 15q21.2

Target Gene Details

• Entrez Gene ID: 84888
• Gene Name: signal peptide peptidase like 2A
• Gene Aliases: IMP3, PSL2
• Location: Chr.15:50702266-50765713 on Build GRCh38
• Assay Gene Location: Within Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SPPL2A	XM_005254722.3	16	3937	XP_005254779.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv471242	Chr.15:50478671 - 50892386 on Build GRCh38	Gain	USP50 TRPM7 USP8 SPPL2A
nsv569398	Chr.15:50496928 - 51002798 on Build GRCh38	Loss	AP4E1 DCAF13P3 USP50 TRPM7 USP8 SPPL2A
nsv1047443	Chr.15:50452584 - 51354826 on Build GRCh38	Gain	GLDN AP4E1 DCAF13P3 MIR7973-2 CYP19A1 PIRC66 SPPL2A TNFAIP8L3 MIR4713 USP50 TRPM7 USP8 MIR7973-1
nsv1051400	Chr.15:50598136 - 50754086 on Build GRCh38	Gain	TRPM7 SPPL2A
dgv2594n100	Chr.15:50469213 - 50823338 on Build GRCh38	Gain	USP50 TRPM7 USP8 SPPL2A
dgv4526n54	Chr.15:50582767 - 51475068 on Build GRCh38	Gain	GLDN AP4E1 DCAF13P3 MIR4713 MIR7973-2 CYP19A1 TRPM7 DMXL2 PIRC66 SPPL2A TNFAIP8L3 MIR7973-1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

aspartic protease

Gene Ontology Categories:

Process(es)

signal peptide processing
membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
regulation of immune response

Function(s)

protein binding
aspartic endopeptidase activity, intramembrane cleaving
protein homodimerization activity