Hs04610003_cn

• Gene Symbol: TANK
• Assay Reference Genome Location: Chr.2:161139721 on build GRCh38
• Cytoband: 2q24.2

Target Gene Details

• Entrez Gene ID: 10010
• Gene Name: TRAF family member associated NFKB activator
• Gene Aliases: I-TRAF, ITRAF, TRAF2
• Location: Chr.2:161136955-161236176 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TANK	NM_004180.2			NP_004171.2
	NM_133484.1			NP_597841.1
	U59863.1			AAC50681.1
	U63830.1			AAC50770.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv955276	Chr.2:161136390 - 161145289 on Build GRCh38	Duplication	TANK
nsv834437	Chr.2:161075774 - 161268203 on Build GRCh38	Gain	TANK LOC100996579 LOC101929512

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

proteolysis
cellular response to DNA damage stimulus
signal transduction
I-kappaB kinase/NF-kappaB signaling
TRIF-dependent toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ionizing radiation
positive regulation of protein deubiquitination
positive regulation of ubiquitin-specific protease activity

Function(s)

thiol-dependent ubiquitin-specific protease activity
protein binding
ubiquitin protein ligase binding
deubiquitinase activator activity
metal ion binding