Hs04753629_cn

• Gene Symbol: PRKCD
• Assay Reference Genome Location: Chr.3:53163648 on build GRCh38
• Cytoband: 3p21.1

Target Gene Details

• Entrez Gene ID: 5580
• Gene Name: protein kinase C delta
• Gene Aliases: ALPS3, CVID9, MAY1, PKCD, nPKC-delta
• Location: Chr.3:53161207-53192717 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRKCD	NM_001316327.1			NP_001303256.1
	NM_006254.3			NP_006245.2
	NM_212539.1			NP_997704.1
	XM_006713259.2			XP_006713322.1
	AK313216.1
	BC043350.1			AAH43350.1
	L07860.1			AAA03176.1
	L07861.1			AAA03175.1
	Z22521.1			CAA80249.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv460554	Chr.3:53145738 - 53194903 on Build GRCh38	Loss	PRKCD
nsv460553	Chr.3:53113560 - 53164998 on Build GRCh38	Loss	PRKCD RFT1
nsv954863	Chr.3:53148285 - 53166784 on Build GRCh38	Deletion	PRKCD
nsv834699	Chr.3:53117860 - 53291778 on Build GRCh38	Loss	DCP1A PRKCD RFT1 TKT
nsv517233	Chr.3:53141541 - 53286984 on Build GRCh38	Loss	DCP1A PRKCD TKT

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
cell cycle
signal transduction
activation of phospholipase C activity
intrinsic apoptotic signaling pathway in response to oxidative stress
regulation of receptor activity
immunoglobulin mediated immune response
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
termination of signal transduction
platelet activation
negative regulation of actin filament polymerization
positive regulation of endodeoxyribonuclease activity
negative regulation of protein binding
activation of protein kinase activity
interleukin-10 production
interleukin-12 production
positive regulation of superoxide anion generation
regulation of actin cytoskeleton organization
negative regulation of glial cell apoptotic process
positive regulation of protein dephosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
neutrophil activation
positive regulation of protein import into nucleus
defense response to bacterium
negative regulation of MAP kinase activity
regulation of mRNA stability
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of peptidyl-tyrosine phosphorylation
protein stabilization
negative regulation of filopodium assembly
cell chemotaxis
interferon-gamma-mediated signaling pathway
cellular response to hydrogen peroxide
cellular response to hydroperoxide
negative regulation of platelet aggregation
cellular senescence
positive regulation of phospholipid scramblase activity
cellular response to angiotensin
positive regulation of ceramide biosynthetic process
positive regulation of glucosylceramide catabolic process
positive regulation of sphingomyelin catabolic process
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
enzyme activator activity
enzyme binding
kinase binding
protein kinase binding
insulin receptor substrate binding
metal ion binding