Hs05153019_cn

• Gene Symbol: MARCH8
• Assay Reference Genome Location: Chr.10:45495569 on build GRCh38
• Cytoband: 10q11.21

Target Gene Details

• Entrez Gene ID: 220972
• Gene Name: membrane associated ring-CH-type finger 8
• Gene Aliases: CMIR, MARCH-VIII, MIR, RNF178, c-MIR
• Location: Chr.10:45454585-45594907 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MARCH8	NM_001002266.2			NP_001002266.1
	NM_001282866.1			NP_001269795.1
	NM_145021.5			NP_659458.2
	XM_005271804.2			XP_005271861.1
	XM_006717704.2			XP_006717767.1
	XM_011539492.2			XP_011537794.1
	XM_011539493.2			XP_011537795.1
	XM_011539494.2			XP_011537796.1
	XM_011539495.1			XP_011537797.1
	XM_017015894.1			XP_016871383.1
	AK057289.1
	AK307667.1
	AK313340.1
	BC025394.2			AAH25394.1
	BC066988.1			AAH66988.1
	BF195460.1
	BG717635.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3623094	Chr.10:45494741 - 45532253 on Build GRCh38	Loss	MARCH8
nsv1043536	Chr.10:45420493 - 45580787 on Build GRCh38	Gain	MARCH8 LOC102724323 ALOX5
esv3891797	Chr.10:45008026 - 45674466 on Build GRCh38	Gain	ZFAND4 RSU1P2 MARCH8 LOC102724323 ANKRD30BP3 OR13A1 MIR3156-1 ALOX5
esv3623093	Chr.10:45486664 - 45500662 on Build GRCh38	Loss	MARCH8
esv3578791	Chr.10:45494709 - 45518597 on Build GRCh38	Loss	MARCH8

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein polyubiquitination
adaptive immune response
antigen processing and presentation of peptide antigen via MHC class II
negative regulation of MHC class II biosynthetic process

Function(s)

ubiquitin-protein transferase activity
zinc ion binding
ligase activity
MHC class II protein binding
ubiquitin protein ligase activity