Hs05223460_cn

• Gene Symbol: NRP1
• Assay Reference Genome Location: Chr.10:33204275 on build GRCh38
• Cytoband: 10p11.22

Target Gene Details

• Entrez Gene ID: 8829
• Gene Name: neuropilin 1
• Gene Aliases: BDCA4, CD304, NP1, NRP, VEGF165R
• Location: Chr.10:33177491-33334905 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRP1	NM_001024628.2			NP_001019799.1
	NM_001024629.2			NP_001019800.1
	NM_001244972.1			NP_001231901.1
	NM_001244973.1			NP_001231902.1
	NM_003873.5			NP_003864.4
	NR_045259.1
	XM_006717521.1			XP_006717584.1
	XM_006717522.1			XP_006717585.1
	XM_006717523.2			XP_006717586.1
	XM_006717524.1			XP_006717587.1
	XM_006717525.1			XP_006717588.1
	XM_006717526.1			XP_006717589.1
	XM_011519755.2			XP_011518057.1
	XM_011519756.1			XP_011518058.1
	XM_017016865.1			XP_016872354.1
	XM_017016866.1			XP_016872355.1
	AA973607.1
	AB209641.1			BAD92878.1
	AF016050.1			AAC12921.1
	AF018956.1			AAC51759.1
	AF145712.1			AAF44344.1
	AF280547.1			AAG41406.1
	AK292822.1
	AL833608.1			CAH10397.1
	AY249243.1			AAP80144.1
	BC007533.1			AAH07533.1
	BC007737.2			AAH07737.1
	BT006995.1			AAP35641.1
	BX510902.1			CAD91133.1
	BX648250.1
	CR749333.1			CAH18187.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831829	Chr.10:33178304 - 33344113 on Build GRCh38	Loss	NRP1 LOC105376488
esv27085	Chr.10:33203541 - 33204375 on Build GRCh38	Loss	NRP1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidoreductase

Gene Ontology Categories:

Process(es)

angiogenesis
patterning of blood vessels
neuron migration
positive regulation of endothelial cell proliferation
sprouting angiogenesis
cell migration involved in sprouting angiogenesis
signal transduction
cell-cell signaling
axon guidance
axonal fasciculation
response to wounding
organ morphogenesis
positive regulation of endothelial cell migration
positive regulation of smooth muscle cell migration
dendrite development
facial nerve structural organization
trigeminal nerve structural organization
vestibulocochlear nerve structural organization
nerve development
branchiomotor neuron axon guidance
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
retinal ganglion cell axon guidance
cellular response to hepatocyte growth factor stimulus
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
ventral trunk neural crest cell migration
VEGF-activated neuropilin signaling pathway
otic placode formation
negative regulation of neuron apoptotic process
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
positive regulation of axon extension involved in axon guidance
negative regulation of axon extension involved in axon guidance
artery morphogenesis
axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of cytokine activity
axonogenesis involved in innervation
regulation of vesicle-mediated transport
dichotomous subdivision of terminal units involved in salivary gland branching
angiogenesis involved in coronary vascular morphogenesis
coronary artery morphogenesis
retina vasculature morphogenesis in camera-type eye
renal artery morphogenesis
sympathetic ganglion development
trigeminal ganglion development
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
commissural neuron axon guidance
regulation of retinal ganglion cell axon guidance
endothelial tip cell fate specification
sensory neuron axon guidance
sympathetic neuron projection extension
sympathetic neuron projection guidance
neural crest cell migration involved in autonomic nervous system development
toxin transport
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
positive regulation of retinal ganglion cell axon guidance
VEGF-activated neuropilin signaling pathway involved in axon guidance
protein localization to early endosome
facioacoustic ganglion development
dorsal root ganglion morphogenesis
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

vascular endothelial growth factor-activated receptor activity
protein binding
heparin binding
coreceptor activity
semaphorin receptor activity
growth factor binding
cytokine binding
vascular endothelial growth factor binding
metal ion binding