Hs05370997_cn

• Gene Symbol: RORA
• Assay Reference Genome Location: Chr.15:60506437 on build GRCh38
• Cytoband: 15q22.2

Target Gene Details

• Entrez Gene ID: 6095
• Gene Name: RAR related orphan receptor A
• Gene Aliases: NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
• Location: Chr.15:60488284-61229303 on Build GRCh38
• Assay Gene Location: Within Intron 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RORA	NM_002943.3			NP_002934.1
	NM_134260.2			NP_599022.1
	NM_134261.2			NP_599023.1
	NM_134262.2			NP_599024.1
	XM_005254584.4			XP_005254641.1
	XM_011521874.1			XP_011520176.1
	XM_011521875.1			XP_011520177.1
	XM_011521877.2			XP_011520179.1
	XM_011521878.1			XP_011520180.1
	XM_011521879.2			XP_011520181.1
	XM_017022466.1			XP_016877955.1
	XM_017022467.1			XP_016877956.1
	AB307694.1
	AL532048.3
	BC008831.2			AAH08831.1
	BC100987.2			AAI00988.1
	BC100988.1			AAI00989.1
	BC100989.1			AAI00990.1
	BC100990.2			AAI00991.1
	HQ692818.1
	HQ709174.1
	L14611.1			AAA02963.1
	U04897.1			AAA62658.1
	U04898.1			AAA62659.1
	U04899.1			AAA62660.1

Target Gene Details

• Entrez Gene ID: 101928784
• Gene Name: RORA antisense RNA 1
• Gene Aliases: -
• Location: Chr.15:60479178-60630639 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RORA-AS1	NR_120339.1
	NR_120340.1
	NR_120341.1
	NR_120342.1
	AW663525.1
	BI668481.1
	BX115309.1
	DA507239.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527607	Chr.15:60454406 - 60507710 on Build GRCh38	Loss	RORA ICE2 RORA-AS1
nsv525689	Chr.15:60448642 - 60531218 on Build GRCh38	Gain	RORA ICE2 RORA-AS1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor

Gene Ontology Categories:

Process(es)

angiogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
xenobiotic metabolic process
nitric oxide biosynthetic process
regulation of smoothened signaling pathway
positive regulation of vascular endothelial growth factor production
regulation of glucose metabolic process
regulation of steroid metabolic process
cerebellar Purkinje cell differentiation
cerebellar granule cell precursor proliferation
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
muscle cell differentiation
positive regulation of circadian rhythm
regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
steroid hormone mediated signaling pathway
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cGMP metabolic process
negative regulation of inflammatory response
regulation of transcription involved in cell fate commitment
triglyceride homeostasis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to hypoxia
T-helper 17 cell differentiation
regulation of cholesterol homeostasis

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcription corepressor binding
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding