Hs05371959_cn

• Gene Symbol: CHRNB4
• Assay Reference Genome Location: Chr.15:78652565 on build GRCh38
• Cytoband: 15q25.1

Target Gene Details

• Entrez Gene ID: 1143
• Gene Name: cholinergic receptor nicotinic beta 4 subunit
• Gene Aliases: -
• Location: Chr.15:78623282-78655586 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CHRNB4	XM_011521186.2			XP_011519488.1
	XM_011521187.2			XP_011519489.1
	AK310443.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1045827	Chr.15:78615314 - 78712300 on Build GRCh38	Gain	CHRNA3 CHRNB4
nsv570202	Chr.15:78622903 - 78661443 on Build GRCh38	Loss	CHRNB4
nsv457208	Chr.15:78615690 - 78727268 on Build GRCh38	Gain	CHRNA3 CHRNB4

More Information

Additional Information:

For this assay, SNP(s) [rs79302803] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

ligand-gated ion channel

Gene Ontology Categories:

Process(es)

action potential
ion transport
smooth muscle contraction
regulation of smooth muscle contraction
signal transduction
synaptic transmission, cholinergic
locomotory behavior
response to nicotine
behavioral response to nicotine
regulation of neurotransmitter secretion
protein heterooligomerization
positive regulation of transmission of nerve impulse
synaptic transmission involved in micturition
cation transmembrane transport

Function(s)

acetylcholine-activated cation-selective channel activity
drug binding
ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine binding
protein heterodimerization activity