Hs05396872_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67170911 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2	1	89	XP_011521726.1
	AK092623.1	1	364
	AK294145.1
	BP215200.1
	CB959673.1
	DA370107.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	TMEM208 EXOC3L1 CTRL ATP6V0D1 PSKH1 MIR328 NUTF2 ENKD1 DDX28 ZDHHC1 THAP11 CENPT LRRC36 NOL3 C16orf86 RANBP10 KIAA0895L CTCF LOC100505942 SLC9A5 LOC100131303 DPEP3 PLEKHG4 LOC105369155 FAM65A NRN1L LRRC29 LCAT KCTD19 PSMB10 DPEP2 FHOD1 CARMIL2 FBXL8 HSD11B2 TSNAXIP1 TPPP3 ELMO3 AGRP PARD6A SLC12A4 EDC4 GFOD2 HSF4 ACD LOC107984813 TRADD E2F4 DUS2
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	TMEM208 NOL3 EXOC3L1 LRRC29 KIAA0895L C16orf70 HSF4 B3GNT9 SLC9A5 TRADD MIR328 FHOD1 PLEKHG4 E2F4 FBXL8 LOC105369155 ELMO3
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	TMEM208 NOL3 EXOC3L1 LRRC29 KIAA0895L C16orf70 HSF4 B3GNT9 TRADD MIR328 FHOD1 E2F4 FBXL8 LOC105369155 ELMO3
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	MIR328 NOL3 EXOC3L1 LRRC29 E2F4 KIAA0895L FBXL8 HSF4 LOC105369155 ELMO3
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	TMEM208 EXOC3L1 CTRL ATP6V0D1 PSKH1 MIR328 NUTF2 ENKD1 DDX28 ZDHHC1 THAP11 CENPT LRRC36 NOL3 C16orf86 RANBP10 KIAA0895L CTCF LOC100505942 SLC9A5 LOC100131303 DPEP3 PLEKHG4 LOC105369155 FAM65A NRN1L LRRC29 LCAT KCTD19 PSMB10 C16orf70 DPEP2 FHOD1 CARMIL2 FBXL8 HSD11B2 TSNAXIP1 TPPP3 ELMO3 AGRP PARD6A SLC12A4 EDC4 GFOD2 HSF4 ACD B3GNT9 LOC107984813 TRADD E2F4 DUS2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding