Hs05419331_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67171561 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2			XP_011521726.1
	AK092623.1	1	1014
	AK294145.1
	BP215200.1
	CB959673.1
	DA370107.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	LOC100505942 TPPP3 CTRL CENPT NOL3 LOC107984813 ELMO3 FAM65A NRN1L KIAA0895L PARD6A MIR328 DPEP3 ZDHHC1 TMEM208 LCAT CTCF HSF4 DUS2 C16orf86 PSKH1 NUTF2 ENKD1 HSD11B2 TSNAXIP1 KCTD19 SLC9A5 RANBP10 GFOD2 FHOD1 TRADD ATP6V0D1 FBXL8 PLEKHG4 THAP11 EXOC3L1 EDC4 LRRC36 ACD LOC105369155 SLC12A4 DDX28 AGRP LRRC29 CARMIL2 LOC100131303 E2F4 DPEP2 PSMB10
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	MIR328 EXOC3L1 LOC105369155 SLC9A5 TMEM208 LRRC29 NOL3 C16orf70 ELMO3 FHOD1 TRADD HSF4 E2F4 B3GNT9 FBXL8 PLEKHG4 KIAA0895L
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	MIR328 EXOC3L1 LOC105369155 TMEM208 LRRC29 NOL3 C16orf70 ELMO3 FHOD1 TRADD HSF4 E2F4 B3GNT9 FBXL8 KIAA0895L
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	LRRC29 NOL3 MIR328 EXOC3L1 LOC105369155 ELMO3 HSF4 E2F4 FBXL8 KIAA0895L
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	LOC100505942 TPPP3 CTRL CENPT NOL3 LOC107984813 ELMO3 FAM65A NRN1L B3GNT9 KIAA0895L PARD6A MIR328 DPEP3 ZDHHC1 TMEM208 LCAT CTCF HSF4 DUS2 C16orf86 PSKH1 NUTF2 ENKD1 HSD11B2 TSNAXIP1 KCTD19 SLC9A5 RANBP10 C16orf70 GFOD2 FHOD1 TRADD ATP6V0D1 FBXL8 PLEKHG4 THAP11 EXOC3L1 EDC4 LRRC36 ACD LOC105369155 SLC12A4 DDX28 AGRP LRRC29 CARMIL2 LOC100131303 E2F4 DPEP2 PSMB10

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding