Hs05420070_cn

• Gene Symbol: WWP2
• Assay Reference Genome Location: Chr.16:69821238 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 11060
• Gene Name: WW domain containing E3 ubiquitin protein ligase 2
• Gene Aliases: AIP2, WWp2-like
• Location: Chr.16:69762284-69941741 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
WWP2	NM_001270454.1			NP_001257383.1
	NM_001270455.1			NP_001257384.1
	NM_007014.4			NP_008945.2
	XM_011522823.2			XP_011521125.1
	XM_011522825.1			XP_011521127.1
	XM_017022879.1			XP_016878368.1
	XM_017022880.1			XP_016878369.1
	XM_017022881.1			XP_016878370.1
	AJ001982.1
	AK295701.1
	AK312792.1
	BC000108.2			AAH00108.1
	BC013645.1			AAH13645.1
	BC064531.1			AAH64531.1
	DC402912.1
	JN712744.1
	U96114.1			AAC51325.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2758652	Chr.16:69821219 - 70279319 on Build GRCh38	Gain+Loss	PDPR SMG1P7 EXOSC6 CLEC18A LOC105371328 AARS LOC107984138 MIR1972-2 CLEC18C PDXDC2P MIR140 WWP2 LOC400541
esv3553617	Chr.16:69820180 - 69824922 on Build GRCh38	Deletion	WWP2
esv3638934	Chr.16:69816425 - 69824178 on Build GRCh38	Gain	WWP2
esv3638935	Chr.16:69820414 - 69824905 on Build GRCh38	Loss	WWP2
esv3892878	Chr.16:69687512 - 69844258 on Build GRCh38	Gain	NQO1 NOB1 WWP2 NFAT5
esv2714666	Chr.16:69820315 - 69824966 on Build GRCh38	Deletion	WWP2
dgv503e199	Chr.16:69820428 - 69824902 on Build GRCh38	Deletion	WWP2
nsv958817	Chr.16:69821077 - 69824912 on Build GRCh38	Deletion	WWP2
nsv1129583	Chr.16:69820782 - 69825118 on Build GRCh38	Tandem Duplication	WWP2
esv3385130	Chr.16:69820791 - 69825075 on Build GRCh38	Duplication	WWP2
esv3638932	Chr.16:69762176 - 69924258 on Build GRCh38	Gain	WWP2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular protein modification process
negative regulation of gene expression
protein ubiquitination
negative regulation of transporter activity
regulation of ion transmembrane transport
regulation of membrane potential
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
viral entry into host cell
negative regulation of protein transport
protein autoubiquitination
protein K63-linked ubiquitination
regulation of potassium ion transmembrane transporter activity

Function(s)

RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
ubiquitin-protein transferase activity
protein binding
transcription factor binding
ligase activity
ubiquitin protein ligase activity