Hs05438192_cn

• Gene Symbol: PLCG2
• Assay Reference Genome Location: Chr.16:81781157 on build GRCh38
• Cytoband: 16q23.3

Target Gene Details

• Entrez Gene ID: 5336
• Gene Name: phospholipase C gamma 2
• Gene Aliases: APLAID, FCAS3, PLC-IV, PLC-gamma-2
• Location: Chr.16:81779258-81962693 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PLCG2	NM_002661.4			NP_002652.2
	AB208914.1			BAD92151.1
	BC007565.1			AAH07565.1
	BC011772.2			AAH11772.1
	BC014561.2			AAH14561.1
	BC018646.2			AAH18646.1
	BP351485.1
	DB456860.1
	M37238.1			AAA60112.1
	X14034.1			CAA32194.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv573365	Chr.16:81771367 - 81942287 on Build GRCh38	Loss	PLCG2 LOC105369213
esv3639343	Chr.16:81755626 - 81815373 on Build GRCh38	Loss	PLCG2 LOC105369213
esv3639339	Chr.16:81696019 - 81869162 on Build GRCh38	Loss	PLCG2 LOC105369213 CMIP
nsv1900	Chr.16:81752035 - 81783699 on Build GRCh38	Insertion	PLCG2 LOC105369213

More Information

Additional Information:

For this assay, SNP(s) [rs72834726] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

phospholipase

Gene Ontology Categories:

Process(es)

positive regulation of receptor internalization
stimulatory C-type lectin receptor signaling pathway
follicular B cell differentiation
phosphatidylinositol biosynthetic process
phospholipid catabolic process
regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
platelet activation
B cell differentiation
activation of store-operated calcium channel activity
positive regulation of type I interferon production
response to lipopolysaccharide
inositol trisphosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of programmed cell death
inositol phosphate metabolic process
T cell receptor signaling pathway
B cell receptor signaling pathway
release of sequestered calcium ion into cytosol

Function(s)

phosphatidylinositol phospholipase C activity
phospholipase C activity
signal transducer activity
protein binding