Hs05574019_cn

• Gene Symbol: TOP3B
• Assay Reference Genome Location: Chr.22:21961006 on build GRCh38
• Cytoband: 22q11.22

Target Gene Details

• Entrez Gene ID: 8940
• Gene Name: topoisomerase (DNA) III beta
• Gene Aliases: TOP3B1
• Location: Chr.22:21954380-21982843 on Build GRCh38
• Assay Gene Location: Within Intron 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TOP3B	NM_001282112.1			NP_001269041.1
	NM_001282113.1			NP_001269042.1
	NM_003935.4			NP_003926.1
	XM_005261811.1			XP_005261868.1
	XM_005261813.2			XP_005261870.1
	XM_006724349.1			XP_006724412.1
	XM_006724350.1			XP_006724413.1
	XM_011530482.1			XP_011528784.1
	XM_017029038.1			XP_016884527.1
	XM_017029039.1			XP_016884528.1
	XM_017029040.1			XP_016884529.1
	XM_017029041.1			XP_016884530.1
	AF017146.1			AAD01614.1
	AF053082.1			AAD15791.1
	AF125216.1			AAD29670.1
	AK096695.1
	AK290997.1
	AK304709.1
	AL833505.1
	BC002432.2			AAH02432.1
	CR456596.1			CAG30482.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv7998n54	Chr.22:21953009 - 22245798 on Build GRCh38	Loss	IGLV6-57 TOP3B VPREB1 PRAMENP
nsv828966	Chr.22:21922751 - 21995911 on Build GRCh38	Loss	PPM1F TOP3B PRAMENP
esv3647324	Chr.22:21955959 - 22114932 on Build GRCh38	Loss	TOP3B PRAMENP
dgv4494n100	Chr.22:21938623 - 22227679 on Build GRCh38	Gain	PPM1F IGLV6-57 TOP3B PRAMENP
esv2422374	Chr.22:21797959 - 22240837 on Build GRCh38	Duplication	PPM1F MAPK1 IGLV6-57 TOP3B PRAMENP
dgv4492n100	Chr.22:21908678 - 21981308 on Build GRCh38	Gain	PPM1F TOP3B
dgv23e196	Chr.22:21865756 - 22219239 on Build GRCh38	Deletion	PPM1F MAPK1 IGLV6-57 TOP3B PRAMENP
dgv1294e212	Chr.22:21956977 - 22224590 on Build GRCh38	Gain	IGLV6-57 TOP3B PRAMENP
nsv1059265	Chr.22:21776836 - 22102744 on Build GRCh38	Gain	PPM1F MAPK1 TOP3B PRAMENP
esv2758826	Chr.22:21940731 - 22054205 on Build GRCh38	Gain+Loss	PPM1F TOP3B PRAMENP
esv3893447	Chr.22:21832190 - 22409194 on Build GRCh38	Gain	PPM1F MAPK1 IGLV6-57 TOP3B VPREB1 IGLV1-44 PRAMENP BMS1P20
esv2760726	Chr.22:21960717 - 22219595 on Build GRCh38	Gain+Loss	IGLV6-57 TOP3B PRAMENP
nsv516394	Chr.22:21936031 - 22229859 on Build GRCh38	Gain+Loss	PPM1F IGLV6-57 TOP3B PRAMENP
nsv1067554	Chr.22:21960940 - 22027424 on Build GRCh38	Loss	TOP3B PRAMENP
nsv469782	Chr.22:21894780 - 22068660 on Build GRCh38	Gain	PPM1F TOP3B PRAMENP
esv2422338	Chr.22:21856644 - 22062991 on Build GRCh38	Deletion	PPM1F MAPK1 TOP3B PRAMENP
esv3647327	Chr.22:21960944 - 22005872 on Build GRCh38	Gain	TOP3B PRAMENP
nsv1160733	Chr.22:21953147 - 22224948 on Build GRCh38	Duplication	IGLV6-57 TOP3B PRAMENP
dgv4495n100	Chr.22:21943275 - 22133198 on Build GRCh38	Gain	PPM1F TOP3B PRAMENP
nsv834146	Chr.22:21894781 - 22068660 on Build GRCh38	Gain	PPM1F TOP3B PRAMENP
esv2763701	Chr.22:21819244 - 22219595 on Build GRCh38	Gain+Loss	PPM1F MAPK1 IGLV6-57 TOP3B PRAMENP
dgv7997n54	Chr.22:21930141 - 22225921 on Build GRCh38	Gain	PPM1F IGLV6-57 TOP3B PRAMENP
dgv22e196	Chr.22:21844035 - 22377218 on Build GRCh38	Deletion	PPM1F MAPK1 IGLV6-57 TOP3B VPREB1 PRAMENP BMS1P20
dgv4493n100	Chr.22:21917856 - 22086088 on Build GRCh38	Gain	PPM1F TOP3B PRAMENP
dgv545n27	Chr.22:21960091 - 22225408 on Build GRCh38	Gain	IGLV6-57 TOP3B PRAMENP
dgv20e196	Chr.22:21789819 - 22087747 on Build GRCh38	Duplication	PPM1F MAPK1 TOP3B PRAMENP
nsv1062641	Chr.22:21803372 - 22013299 on Build GRCh38	Gain	PPM1F MAPK1 TOP3B PRAMENP

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

DNA topological change
chromosome segregation

Function(s)

DNA binding
DNA topoisomerase activity
DNA topoisomerase type I activity
protein binding
poly(A) RNA binding