Hs05587106_cn

• Gene Symbol: IL2RB
• Assay Reference Genome Location: Chr.22:37131519 on build GRCh38
• Cytoband: 22q12.3

Target Gene Details

• Entrez Gene ID: 3560
• Gene Name: interleukin 2 receptor subunit beta
• Gene Aliases: CD122, IL15RB, P70-75
• Location: Chr.22:37125838-37149922 on Build GRCh38
• Assay Gene Location: Within Intron 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IL2RB	NM_000878.3			NP_000869.1
	AK312860.1
	BC025691.1			AAH25691.1
	CR456506.1			CAG30392.1
	M26062.1			AAA59143.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv829203	Chr.22:36998126 - 37773322 on Build GRCh38	Loss	CDC42EP1 LGALS1 IL2RB KCTD17 CYTH4 TRIOBP PDXP MPST GGA1 C1QTNF6 SH3BP1 SSTR3 TEX33 LGALS2 ELFN2 NOL12 TST LOC100506271 CARD10 LOC102724378 LOC101927051 MFNG RAC2 TMPRSS6
nsv834187	Chr.22:36965603 - 37163260 on Build GRCh38	Loss	TEX33 LL22NC01-81G9.3 IL2RB KCTD17 TST MPST TMPRSS6
esv34015	Chr.22:36966049 - 37189804 on Build GRCh38	Loss	TEX33 LL22NC01-81G9.3 IL2RB KCTD17 TST MPST C1QTNF6 TMPRSS6
nsv459882	Chr.22:36967923 - 37161398 on Build GRCh38	Gain	TEX33 LL22NC01-81G9.3 IL2RB KCTD17 TST MPST TMPRSS6

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
protein complex assembly
signal transduction
viral process
cytokine-mediated signaling pathway
natural killer cell activation
interleukin-2-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of GTPase activity

Function(s)

interleukin-2 receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
interleukin-2 binding