Hs05908565_cn

• Gene Symbol: CASP3
• Assay Reference Genome Location: Chr.4:184635064 on build GRCh38
• Cytoband: 4q35.1

Target Gene Details

• Entrez Gene ID: 836
• Gene Name: caspase 3
• Gene Aliases: CPP32, CPP32B, SCA-1
• Location: Chr.4:184627696-184649475 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CASP3	NM_004346.3			NP_004337.2
	NM_032991.2			NP_116786.1
	XM_011532301.1			XP_011530603.1
	AJ413269.1			CAC88866.1
	AK291337.1
	AU127028.1
	AU133051.1
	BC016926.2			AAH16926.1
	BX647609.1			CAI46084.1
	U13737.1			AAA65015.1
	U13738.1			AAB60355.1
	U26943.1			AAA74929.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv830168	Chr.4:184626297 - 184801578 on Build GRCh38	Loss	CASP3 SLED1 PRIMPOL ACSL1 CENPU
nsv1026074	Chr.4:184384963 - 184780663 on Build GRCh38	Gain	LVCAT8 CASP3 PRIMPOL ACSL1 IRF2 CENPU

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

response to hypoxia
B cell homeostasis
apoptotic DNA fragmentation
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular component disassembly involved in execution phase of apoptosis
cellular response to DNA damage stimulus
heart development
sensory perception of sound
learning or memory
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
response to UV
response to glucose
response to X-ray
regulation of macroautophagy
protein processing
hippocampus development
neuron differentiation
keratinocyte differentiation
erythrocyte differentiation
platelet formation
negative regulation of B cell proliferation
response to cobalt ion
response to estradiol
response to lipopolysaccharide
glial cell apoptotic process
response to tumor necrosis factor
response to nicotine
hippo signaling
wound healing
response to drug
response to hydrogen peroxide
T cell homeostasis
negative regulation of apoptotic process
response to amino acid
positive regulation of neuron apoptotic process
cell fate commitment
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of activated T cell proliferation
response to antibiotic
neurotrophin TRK receptor signaling pathway
response to glucocorticoid
neuron apoptotic process
cellular response to organic cyclic compound
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
execution phase of apoptosis

Function(s)

protease binding
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
death receptor binding
protein binding
peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
phospholipase A2 activator activity
protein complex binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in execution phase of apoptosis