Hs05915460_cn

• Gene Symbol: TLR6
• Assay Reference Genome Location: Chr.4:38839605 on build GRCh38
• Cytoband: 4p14

Target Gene Details

• Entrez Gene ID: 10333
• Gene Name: toll like receptor 6
• Gene Aliases: CD286
• Location: Chr.4:38822897-38857767 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TLR6	NM_006068.4			NP_006059.2
	XM_005262637.4			XP_005262694.1
	XM_011513612.2			XP_011511914.1
	XM_011513613.2			XP_011511915.1
	XM_011513614.2			XP_011511916.1
	AK313618.1
	DA619469.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3600267	Chr.4:38809373 - 38862827 on Build GRCh38	Loss	TLR6
esv2672127	Chr.4:38809351 - 38862791 on Build GRCh38	Deletion	TLR6
nsv594010	Chr.4:38804398 - 38873181 on Build GRCh38	Loss	MIR574 TLR1 TLR6 FAM114A1
esv2762427	Chr.4:38809930 - 38848489 on Build GRCh38	Loss	TLR6

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
toll-like receptor 6 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
innate immune response
positive regulation of interleukin-6 biosynthetic process
interleukin-1 beta secretion
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly

Function(s)

receptor activity
transmembrane signaling receptor activity
protein binding
Toll-like receptor 2 binding
lipopeptide binding