Hs05965055_cn

• Gene Symbol: KDR
• Assay Reference Genome Location: Chr.4:55100547 on build GRCh38
• Cytoband: 4q12

Target Gene Details

• Entrez Gene ID: 3791
• Gene Name: kinase insert domain receptor
• Gene Aliases: CD309, FLK1, VEGFR, VEGFR2
• Location: Chr.4:55078259-55125595 on Build GRCh38
• Assay Gene Location: Within Intron 15

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KDR	NM_002253.2			NP_002244.1
	AB209901.1			BAD93138.1
	AF035121.1			AAB88005.1
	AF063658.1			AAC16450.1
	BC131822.1
	L04947.1			AAA59459.1
	X61656.1			CAA43837.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv526344	Chr.4:54656321 - 55364952 on Build GRCh38	Gain	SRD5A3 KDR KIT
nsv829939	Chr.4:54990604 - 55138844 on Build GRCh38	Gain	KDR

More Information

Additional Information:

For this assay, SNP(s) [rs116530298] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

angiogenesis
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
positive regulation of macroautophagy
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
extracellular matrix organization
positive regulation of cell migration
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
positive regulation of mitochondrial depolarization
positive regulation of ERK1 and ERK2 cascade
positive regulation of mitochondrial fission
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis

Function(s)

protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
Hsp90 protein binding