Hs06007905_cn

• Gene Symbol: DOCK2
• Assay Reference Genome Location: Chr.5:169660798 on build GRCh38
• Cytoband: 5q35.1

Target Gene Details

• Entrez Gene ID: 1794
• Gene Name: dedicator of cytokinesis 2
• Gene Aliases: IMD40
• Location: Chr.5:169637247-170083382 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DOCK2	NM_004946.2			NP_004937.1
	XM_005265830.3			XP_005265887.1
	XM_011534448.2			XP_011532750.1
	XM_011534449.2			XP_011532751.1
	XM_011534450.2			XP_011532752.1
	XM_011534451.2			XP_011532753.1
	XM_017009189.1			XP_016864678.1
	XM_017009190.1			XP_016864679.1
	BC104900.1			AAI04901.1
	BC113457.1
	D86964.1
	DB145764.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv5124	Chr.5:169631419 - 169676697 on Build GRCh38	Deletion	DOCK2
nsv1031257	Chr.5:169272339 - 169832306 on Build GRCh38	Gain	DOCK2 SLIT3 SPDL1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor

Gene Ontology Categories:

Process(es)

membrane raft polarization
establishment of T cell polarity
immunological synapse formation
myeloid dendritic cell activation involved in immune response
chemotaxis
small GTPase mediated signal transduction
actin cytoskeleton organization
positive regulation of GTPase activity
macropinocytosis
positive thymic T cell selection
negative thymic T cell selection
alpha-beta T cell proliferation
regulation of defense response to virus by virus
positive regulation of phagocytosis

Function(s)

GTPase activator activity
protein binding
Rac guanyl-nucleotide exchange factor activity
T cell receptor binding