Hs06785645_cn

• Gene Symbol: HDAC2
• Assay Reference Genome Location: Chr.6:113970728 on build GRCh38
• Cytoband: 6q21

Target Gene Details

• Entrez Gene ID: 3066
• Gene Name: histone deacetylase 2
• Gene Aliases: HD2, RPD3, YAF1
• Location: Chr.6:113936156-113971195 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HDAC2	NM_001527.3			NP_001518.3
	NR_033441.1
	NR_073443.1
	XM_017010799.1			XP_016866288.1
	AK092156.1
	AK097376.1
	AK296856.1
	BC031055.1			AAH31055.2
	BP201509.1
	U31814.1			AAC50814.1

Target Gene Details

• Entrez Gene ID: 101927768
• Gene Name: uncharacterized LOC101927768
• Gene Aliases: -
• Location: Chr.6:113969701-114340729 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC101927768	NR_125845.1
	CD643945.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv520419	Chr.6:113964089 - 113985450 on Build GRCh38	Loss	HDAC2 LOC101927768

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
cardiac muscle hypertrophy
chromatin remodeling
maintenance of chromatin silencing
transcription, DNA-templated
blood coagulation
positive regulation of cell proliferation
epidermal cell differentiation
positive regulation of epithelial to mesenchymal transition
positive regulation of receptor biosynthetic process
negative regulation of neuron projection development
dendrite development
histone deacetylation
response to caffeine
response to lipopolysaccharide
positive regulation of interleukin-1 production
positive regulation of tumor necrosis factor production
circadian regulation of gene expression
positive regulation of collagen biosynthetic process
cellular response to heat
response to nicotine
response to cocaine
odontogenesis of dentin-containing tooth
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
embryonic digit morphogenesis
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of MHC class II biosynthetic process
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
behavioral response to ethanol
positive regulation of oligodendrocyte differentiation
response to hyperoxia
hair follicle placode formation
negative regulation of dendritic spine development
eyelid development in camera-type eye
fungiform papilla formation
cellular response to hydrogen peroxide
histone H3 deacetylation
histone H4 deacetylation
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
regulation of signal transduction by p53 class mediator
cellular response to dopamine
negative regulation of peptidyl-lysine acetylation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
chromatin binding
histone deacetylase activity
protein binding
transcription factor binding
deacetylase activity
enzyme binding
heat shock protein binding
nucleosomal DNA binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
sequence-specific DNA binding
poly(A) RNA binding
NF-kappaB binding