Mm00135621_cn

• Gene Symbol: Tgfbr1
• Assay Reference Genome Location: Chr.4:47407068 on build GRCm38
• Cytoband: 4B1

Target Gene Details

• Entrez Gene ID: 21812
• Gene Name: transforming growth factor, beta receptor I
• Gene Aliases: ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI
• Location: Chr.4:47353113-47414926 on Build GRCm38
• Assay Gene Location: Overlaps Exon 8 - Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
Tgfbr1	NM_009370.2			NP_033396.1
	AK007125.1			BAB24865.1
	AK015337.1			BAB29802.1
	AK154381.1			BAE32548.1
	BC063260.1			AAH63260.1
	CT010393.1			CAJ18600.1
	D25540.1			BAA05023.1
	D28526.1			BAA05878.1

More Information

• Set Membership: Intragenic, Non-exonic

Panther Classification:

Molecular Function -

serine/threonine protein kinase receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
skeletal system development
angiogenesis
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
negative regulation of endothelial cell proliferation
lens development in camera-type eye
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
germ cell migration
male gonad development
embryo development
post-embryonic development
anterior/posterior pattern specification
regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cell differentiation
collagen fibril organization
positive regulation of cell growth
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
regulation of growth
negative regulation of apoptotic process
regulation of protein binding
endothelial cell migration
response to estrogen
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
protein autophosphorylation
thymus development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
artery morphogenesis
cell motility
positive regulation of cellular component movement
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
response to cholesterol
cellular response to transforming growth factor beta stimulus
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
type II transforming growth factor beta receptor binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor binding
ubiquitin protein ligase binding
protein complex binding
SMAD binding
metal ion binding
protein heterodimerization activity
transforming growth factor beta binding
I-SMAD binding