Mm00393124_cn

• Gene Symbol: Isl1
• Assay Reference Genome Location: Chr.13:116301690 on build GRCm38
• Cytoband: 13D2.2

Target Gene Details

• Entrez Gene ID: 16392
• Gene Name: ISL1 transcription factor, LIM/homeodomain
• Gene Aliases: -
• Location: Chr.13:116298257-116309721 on Build GRCm38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
Isl1	NM_021459.4	5	1120	NP_067434.3
	AB104633.1			BAC57891.1
	AJ132765.1	5	986	CAB38446.1
	AK090263.1	5	1121	BAC41153.1
	BC132263.1	5	1046
	BC132609.1	5	1046
	CF725499.1
	EU704681.1	2	178

More Information

• Set Membership: Intragenic, Exonic

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
heart morphogenesis
secondary heart field specification
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
regulation of secondary heart field cardioblast proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
heart development
positive regulation of cell proliferation
regulation of gene expression
positive regulation of vascular endothelial growth factor production
spinal cord motor neuron cell fate specification
spinal cord motor neuron differentiation
visceral motor neuron differentiation
trigeminal nerve development
pituitary gland development
neuron differentiation
pancreas development
retinal ganglion cell axon guidance
positive regulation of insulin secretion
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of intracellular estrogen receptor signaling pathway
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of DNA binding
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate specification
mesenchymal cell differentiation
sensory system development
peripheral nervous system neuron development
peripheral nervous system neuron axonogenesis
negative regulation of inflammatory response
ventricular cardiac muscle tissue morphogenesis
pharyngeal system development
cardiac muscle cell myoblast differentiation
innervation
atrial septum morphogenesis
cardiac cell fate determination
positive regulation of granulocyte colony-stimulating factor production
negative regulation of protein homodimerization activity
negative regulation of canonical Wnt signaling pathway
positive regulation of macrophage colony-stimulating factor production

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
bHLH transcription factor binding
sequence-specific DNA binding
metal ion binding