Hs00233284_m1

• Gene Symbol: IKBKB
• Gene Name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
• Gene Aliases: IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
• Chromosome Location: Chr.8: 42271302 - 42332653 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: IKBKB
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_001190720.2	NP_001177649.1	4 - 5	453		90
	NM_001242778.1	NP_001229707.1	4 - 5	481		90
	NM_001556.2	NP_001547.1	5 - 6	576		90
	NR_033819.1		5 - 6	576		90
	NR_040009.1		5 - 6	576		90
	XM_005273490.2	XP_005273547.1	5 - 6	576		90
	XM_005273491.4	XP_005273548.1	4 - 5	476		90
	XM_005273492.3	XP_005273549.1	5 - 6	576		90
	XM_005273494.2	XP_005273551.1	5 - 6	576		90
	XM_005273495.2	XP_005273552.1	5 - 6	442		90
	XM_005273496.3	XP_005273553.1	4 - 5	462		90
	XM_011544517.2	XP_011542819.1	5 - 6	574		90
	XM_011544518.2	XP_011542820.1	5 - 6	576		90
	XM_011544519.2	XP_011542821.1	4 - 5	444		90
GenBank mRNA	AB209090.1	-	4 - 5	394		90
	AF029684.1	-	4 - 5	390		90
	AF031416.1	-	4 - 5	390		90
	AF080158.1	-	5 - 6	533		90
	AK290952.1	-	5 - 6	442		90
	AK298241.1	-	2 - 3	140		90
	AK302723.1	-	4 - 5	437		90
	AK303294.1	-	4 - 5	465		90
	AK303528.1	-	4 - 5	469		90
	AK316418.1	-	4 - 5	437		90
	BC006231.2	-	5 - 6	560		90
	BC108694.1	-	5 - 6	488	5784717	90
	BC144080.1	-	4 - 5	420		90
	BX648165.1	-	4 - 5	1028		90

More Information

Additional Information:

This assay is in the 5'UTR region of the XM_005273495.2, XM_005273496.3 transcripts.

• Set Membership: Ambion siRNA available, Amplicon length between 86 and 100, Protein Kinase, Mammalian Gene Collection, Homo sapiens, Human Immune Response, Human NFkB Pathway, Human Apoptosis, 1700, Inventoried, Human_Immune, Human_Nfkb, Human_Apoptosis, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene IKBKB

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

stimulatory C-type lectin receptor signaling pathway
skeletal muscle contraction
protein phosphorylation
inflammatory response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
positive regulation of cell proliferation
response to virus
response to toxic substance
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
cortical actin cytoskeleton organization
neuron projection development
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
negative regulation of myosin-light-chain-phosphatase activity
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
regulation of phosphorylation
response to drug
serine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
interleukin-1-mediated signaling pathway
response to fatty acid
cellular response to tumor necrosis factor
establishment of protein localization to plasma membrane
positive regulation of neuron death
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
protein kinase binding
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
ABI Human Genome Survey Microarray Version 2.0	220579	-	-