Hs05029263_s1

• Gene Symbol: HMGCR
• Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase
• Gene Aliases: LDLCQ3
• Chromosome Location: Chr.5: 75336334 - 75362101 on Build GRCh38
• Species: Human
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: HMGCR
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_000859.2	NP_000850.1	6	671		72
	NM_001130996.1	NP_001124468.1	6	671		72
	XM_011543357.1	XP_011541659.1	6	822		72
	XM_011543358.1	XP_011541660.1	6	709		72
	XM_011543359.1	XP_011541661.1	6	822		72
GenBank mRNA	AK292892.1	-	6	602		72
	AK296499.1	-	6	826		72
	AK312437.1	-	5	515		72
	AY429542.1	-	2	126		72
	BC033692.1	-	6	607	5212903	72
	M11058.1	-	6	565		72

More Information

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Mammalian Gene Collection, Detect Genomic DNA, Homo sapiens, Both primers and probe map within a single exon

Matching Ambion siRNAs:

Click here to find siRNAs for Gene HMGCR

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

cholesterol biosynthetic process
ubiquinone metabolic process
aging
response to nutrient
isoprenoid biosynthetic process
visual learning
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
myoblast differentiation
response to ethanol
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade

Function(s)

hydroxymethylglutaryl-CoA reductase (NADPH) activity
protein binding
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
coenzyme binding
protein phosphatase 2A binding
NADPH binding