Mm00436965_m1

• Gene Symbol: Tgfbr1
• Gene Name: transforming growth factor, beta receptor I
• Gene Aliases: ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI
• Chromosome Location: Chr.4: 47353113 - 47414926 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Tgfbr1
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_009370.2	NP_033396.1	2 - 3	337		71
GenBank mRNA	AK154381.1	-	1 - 2	100		71
	BC063260.1	-	2 - 3	337	6409765	71
	CT010393.1	-	2 - 3	330		71
	D28526.1	-	2 - 3	330		71

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0400000519.mm.1

• Set Membership: Ambion siRNA available, Amplicon length between 71 and 85, Protein Kinase, Mammalian Gene Collection, Mus musculus, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Tgfbr1

Panther Classification:

Molecular Function -

serine/threonine protein kinase receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
skeletal system development
angiogenesis
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
negative regulation of endothelial cell proliferation
lens development in camera-type eye
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
germ cell migration
male gonad development
embryo development
post-embryonic development
anterior/posterior pattern specification
regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cell differentiation
collagen fibril organization
positive regulation of cell growth
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
regulation of growth
negative regulation of apoptotic process
regulation of protein binding
endothelial cell migration
response to estrogen
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
protein autophosphorylation
thymus development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
artery morphogenesis
cell motility
positive regulation of cellular component movement
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
response to cholesterol
cellular response to transforming growth factor beta stimulus
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
type II transforming growth factor beta receptor binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor binding
ubiquitin protein ligase binding
protein complex binding
SMAD binding
metal ion binding
protein heterodimerization activity
transforming growth factor beta binding
I-SMAD binding

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0400003827.mm.1	NM_009370.3	Refseq
Affymetrix Mouse Clariom S Array	PSR0400003827.mm.1	TC0400000519.mm.1	MTA TC