Mm00446191_m1

• Gene Symbol: Il6
• Gene Name: interleukin 6
• Gene Aliases: Il-6
• Chromosome Location: Chr.5: 30013161 - 30019968 on Build GRCm38
• Species: Mouse
• Species Specific ID (Flybase ID): -

Assay Details

Gene Symbol: Il6
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_031168.1	NP_112445.1	3 - 4	347		124
GenBank mRNA	AK089780.1	-	3 - 4	366		124
	AK150440.1	-	3 - 4	366		124
	AK152189.1	-	2 - 3	353		124
	BC132458.1	-	3 - 4	340	40130735	124
	BC138766.1	-	3 - 4	340	8861788	124
	BC145409.1	-	3 - 4	340		124
	DQ788722.1	-	3 - 4	316		124
	J03783.1	-	3 - 4	364		124
	X06203.1	-	3 - 4	349		124
	X54542.1	-	3 - 4	347		124

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC0500000283.mm.1

• Set Membership: Ambion siRNA available, Amplicon length greater than or equal to 101, Apoptosis, Mammalian Gene Collection, Mus musculus, Mouse lipid regulated genes, Inventoried, Mouse_lipid_regulated_genes, Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Il6

Gene Ontology Categories:

Process(es)

neutrophil apoptotic process
myeloid cell homeostasis
hepatic immune response
positive regulation of acute inflammatory response
negative regulation of protein kinase activity
acute-phase response
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of vascular endothelial growth factor production
positive regulation of gene expression
cell growth
cytokine-mediated signaling pathway
endocrine pancreas development
neuron projection development
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein import into nucleus, translocation
positive regulation of T cell proliferation
T cell activation
regulation of cell proliferation
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
defense response to protozoan
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of chemokine biosynthetic process
regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of nitric oxide biosynthetic process
cell redox homeostasis
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of gluconeogenesis
positive regulation of translation
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
muscle cell cellular homeostasis
negative regulation of hormone secretion
negative regulation of muscle organ development
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
defense response to virus
positive regulation of protein kinase B signaling
positive regulation of transmission of nerve impulse
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
T-helper 17 cell lineage commitment
negative regulation of neuron death

Function(s)

receptor binding
cytokine activity
interleukin-6 receptor binding
protein binding
growth factor activity

MicroArray Probes:

Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR0500002169.mm.1	TC0500000283.mm.1	MTA TC
Affymetrix Mouse Clariom S Array	PSR0500002169.mm.1	NM_031168.2	Refseq